Polysorbate 80

Chembox new
Reference= ["Merck Index", 13th Edition, 7664.]
Name = Polysorbate 80
ImageFile = Polysorbate 80.png ImageSize = 275px
ImageName =
IUPACName = Polyoxyethylene (20) sorbitan monooleate
OtherNames = Tween 80
Section1 = Chembox Identifiers
CASOther = [9005-65-6]
RTECS = WG2932500
Section2 = Chembox Properties
Formula = C₆₄H₁₂₄O₂₆
MolarMass = 1310 g/mol
Appearance = Amber colored viscous liquid
Density = 1.06-1.09 g/mL, oily liquid
Viscosity = 300-500 centistokes (@25°C)
Solubility = Very soluble
Solvent = other solvents
SolubleOther = soluble in ethanol, cottonseed oil, corn oil, ethyl acetate, methanol, toluene
MeltingPt =
BoilingPt = > 100°C
Section7 = Chembox Hazards
MainHazards = Irritant
NFPA-H = 1
NFPA-F =
NFPA-R =
FlashPt = 113 °C

Polysorbate 80 (commercially also known as Tween 80, a registered trademark of ICI Americas, Inc.) [ [http://tarr.uspto.gov/servlet/tarr?regser=registration&entry=2885675 US PTO TESS Registry Number 2885675] ] is a nonionic surfactant and emulsifier derived from polyethoxylated sorbitan and oleic acid, and is often used in foods. Polysorbate 80 is a viscous, water-soluble yellow liquid. The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups which are polymers of ethylene oxide. In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case the oleic acid (see polysorbate for more detail).

Polysorbate 80 is often used in ice cream to prevent milk proteins from completely coating the fat droplets. This allows them to join together in chains and nets, to hold air in the mixture, and provide a firmer texture, holding its shape as the ice cream melts.

Other names

*Polyoxyethylene (20) sorbitan monooleate
*(x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl)
*Tween 80
*POE (20) sorbitan monooleate

Polysorbate 80 is also used in some eye drops (i.e. ROHTO cool redness reliever/lubricant eye drops)

Data

The critical micelle concentration of polysorbate 80 is reported as 0.012 mMcite journal |author=Chou DK, Krishnamurthy R, Randolph TW, Carpenter JF, Manning MC |title=Effects of Tween 20 and Tween 80 on the stability of Albutropin during agitation |journal=J Pharm Sci |volume=94 |issue=6 |pages=1368–81 |year=2005 |month=June |pmid=15858848 |doi=10.1002/jps.20365 |url=] and 0.006mM.cite journal
author = Marc Thorsteinsson, et al
journal = Analytical Biochemistry
title = 5-Dodecanoylaminofluorescein as a probe for the determination of crticial micelle concentration of detergents using fluorescence anisotropy
year = 2005
volume = 340
pages = 220–225
doi = 10.1016/j.ab.2005.01.006]

Medical use

Polysorbate 80 is used as an emulsifier in the manufacture of medications for parenteral administration, most notably in the popular anti-arrhythmic amiodarone. [cite web
last = Gautier & Bellamy
title = Pharmaceutical amiodarone composition for parenteral delivery
|url = http://www.patentstorm.us/patents/6143778.html
accessdate = 2008-04-06]

ee also

*Polysorbate 20: Used as a wetting agent in mouth drops.
*Polysorbate 40
*Polysorbate 60: Used as an emulsifier in powdered drink preparations such as hot cocoa mix.
*Polysorbate 65

References

External links

*http://www.chemexper.com/index.shtml?main=http://www.chemexper.com/search/cas/9005-65-6.html