- Stollé synthesis
The Stollé synthesis is a series of
chemical reaction s that produceoxindole s fromaniline s and α-haloacid chlorides (oroxalyl chloride ). [Stollé, R. "Ber. " 1913, "46", 3915.] [Stollé, R. "Ber. " 1914, "47", 2120.] [Stollé, R. "J. Prakt. Chem." 1923, "105", 137.] [Stollé, R. "J. Prakt. Chem." 1930, "128", 1.]The first step is an
amide coupling, while the second step is aFriedel-Crafts reaction . [Sumpter, W. C. "Chem. Rev. " 1944, "34", 396. (Review)] [Sumpter, W. C. "Chem. Rev. " 1945, "37", 446. (Review)] An improved procedure has been developed. [Julian; Pikl "J. Am. Chem. Soc. " 1935, "57", 563.] [Rutenberg, M. W.; Horning, E. C. "Organic Syntheses ", Coll. Vol. 4, p.620 (1963); Vol. 30, p.62 (1950). ( [http://www.orgsyn.org/orgsyn/prep.asp?prep=cv4p0620 Article] )]References
ee also
*
Indole
*Hinsberg oxindole synthesis
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