Fujimoto-Belleau reaction
- Fujimoto-Belleau reaction
The Fujimoto-Belleau reaction is a chemical reaction that forms cyclic α-substituted α,β-unsaturated ketones from enol lactones. The reaction is named after the two chmists George I. Fujimoto and Bernard Belleau.
The reaction is a Grignard reaction, followed by a H-shift and an Aldol addition reaction. The last step is an elimination (Aldol condensation) reaction with an E1"CB" mechanism.
References
* cite journal
title = Labeling of Steroids in the 4-Position
author = George I. Fujimoto
journal = J. Am. Chem. Soc.
volume = 73
issue =
pages = 1856–1856
year = 1951
url =
doi = 10.1021/ja01148a518
* cite journal
title = The Reaction of Methylmagnesium Iodide with β-(1-Hydroxy-3,4-dihydro-2-naphthyl)-butyric Acid Lactone
author = Bernard Belleau
journal = J. Am. Chem. Soc.
volume = 73
issue =
pages = 5441–5443
year = 1951
url =
doi = 10.1021/ja01155a504
* Weill-Raynal, J. "Synthesis" 1969, 49.
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