LaSIGE (Large-Scale Informatic Systems Laboratory, Portuguese Laboratório de Sistemas Informáticos de Grande Escala) is a research unit of the Computer Science department of the Faculty of Sciences of the University of Lisbon, located at the Faculty's C6 building.
LaSIGE's research activities are organized around different topics, promoting research, training and technology transfer. The current research lines are:
- Biomedical informatics
- Communication System Software and Middleware
- Fault and Intrusion Tolerance in Open Distributed Systems
- Global Computing
- Human Computer Interaction and Multimedia
- Information Management
- Timeliness and Adaptation in Dependable Systems.
Research at LaSIGE is currently conducted by four research teams:
- Gloss - Group of Software Systems
- HCIM - Human Computer Interaction and Multimedia
- Navigators - Distributed Systems
- XLDB Team - Data management and Biomedical informatics
A research team on distributed systems, their architectures, their algorithms, in their several skins: fault tolerance, real-time, security, and combinations thereof.
The XLDB team researches data management problems with a focus on systems for data analyses, information integration and user access to large quantities of complex data from heterogeneous platforms. Current research lines span geographic information retrieval, text mining and natural language processing, web archiving and search, information visualisation, and bioinformatics.
Some projects and researchers have been granted awards for their research work, namely: 
- Honorable Mention on the Descartes Prize 2004, for project MAFTIA.
- 2004 IBM Scientific Prize, for researcher Nuno Ferreira Neves.
- Innovation Young Engineer 2004 Prize, for researcher Francisco Couto.
- Elevation of Professor Paulo Verissimo to IEEE Fellow in 2007, and ACM Fellow in 2009.
- 2007 IBM Scientific Prize, for researcher Paulo Sousa.
- LaSIGE former team:
Wikimedia Foundation. 2010.