SC

SC may refer to:
* Saint Kitts and Nevis, NATO country code
* Seychelles, ISO 3166-1 alpha-2 country code, SC
* South Carolina, United States postal abbreviation
* Sumter and Choctaw Railway reporting mark|SC
* Shandong Airlines, IATA airline designator
* Santa Catarina (state), Brazil (ISO 3166-2:BR)
* A USCS symbol for "clayey sand"

In medicine:
* Secretory component
* Stem cell
* Subcutaneous
* Superior colliculus

In computer, video games, and television:
* SimCity, a computer game
* Soulcalibur, Namco's popular fighting game series
* Splinter Cell, a computer game by Ubisoft
* Star Control, computer game
* StarCraft, computer game
* Steambot Chronicles
* Strike Commander, computer game
* Supreme Commander, computer game
* Sven Co-op, A Half-Life modification
* Sandy Cheeks, character in "SpongeBob SquarePants"
* Sally Carrera, character in "Cars" and "Cars 2"

SC may also be:
* Science Channel
* Cruiser Submarine, US Navy hull classification
* Safety Car, a vehicle which controls the speed of competitors in an automobile race for safety reasons
* Santa Cruz
* Sam's Club
* Samurai Champloo
* Scheduled castes, the disadvantaged castes of India commonly known as Dalits
* The United Nations Security Council
* A United Nations Security Clearance
* Senior Counsel
* Sha Tin College, an ESF (English Schools Foundation) school in Sha Tin, Hong Kong. Also registered IB world school
* Shortcut
* Short course, swimming in a 25 m pool
* Simplified Chinese
* Skate Canada
* SmarterChild, an AOL Instant Messenger bot
* Smithtown Christian School
* Soccer Club (in some countries it may stand for "Sports Club", but the main sport played may still be soccer)
* Solar cell
* Space Cowboy
* Special Circumstances
* Special Constable
* Spice Channel
* SportsCenter, An American Sports show
* SportsCentre, A Canadian Sports show
* Springfield College
* Star of Courage
** Star of Courage (Australia) (Australian decoration)
** Star of Courage (Canadian decoration post-nominal letters)
* Stone Cold Steve Austin
* Sternoclavicular joint of the human body and other animals
* Suicide Chess
* The Supreme Court, in some countries
* University of South Carolina
* University of Southern California
* A type (SC) of optical fiber connector, of a push-pull coupling style
* The School Certificate, an accreditation issued by the New South Wales Board of Studies, typically at the completion of Year 10
* Lexus SC, the mid-sized coupe from made by Lexus
* Service Corporation in Wisconsin, similar to Professional Associations (PA) or Professional Corporation (PC) in some other states

Sc may refer to:
* Scandium (Sc symbol for the chemical element)
* Schmidt number, in fluid dynamics
* Sc, the abbreviation for the orchid genus "Sophrocattleya"

sc may refer to:
* Sardinian language (ISO 639 alpha-2, sc)
* strip club
* SuperCollider programming language
* saltwater crocodile

sc is a digraph in some languages
* in Italian and some closely related languages, and also in Old English it makes the voiceless postalveolar fricative [ʃ] sound

sc. is an abbreviation of
* "scilicet"