Adie syndrome

Adie syndrome

Name = Adie syndrome

Caption =
DiseasesDB = 29742
ICD10 =
ICD9 = ICD9|379.46
MedlinePlus =
eMedicineSubj =
eMedicineTopic =
MeshID = D015845

Adie syndrome, sometimes known as Holmes-Adie's syndrome or Adie's Tonic Pupil, is a neurological disorder which affects the pupil of the eye and the autonomic nervous system.cite web |url= |title= Holmes-Adie syndrome Information Page | author= |publisher=National Institute of Neurological Disorders and Stroke|accessdate=2008-01-21 |format= |work=] It is caused by damage to the postganglionic fibers of the parasympathetic innervation of the eye, usually by a viral or bacterial infection which causes inflammation, and characterized by a tonically dilated pupil.

igns and Symptoms

Adie syndrome presents with three hallmark symptoms, namely abnormal pupil size (mydriasis), loss of deep tendon reflexes and diaphoresis. Other signs may include hyperopia due to accommodative paresis, photophobia and difficulty reading.cite book | last = | first = | authorlink = | coauthors = | title = Stedman's Medical Dictionary, 27th Edition | publisher = | date = 2000 | location = | pages = | url = | doi = | id = | isbn = 0-683-40007-X]


Clinical exam may reveal sectoral paresis of the iris sphincter and/or vermiform iris movements. The tonic pupil may become smaller (miotic) over time which is referred to as "little old Adie's".cite book | last = Haines | first = Duane E. | authorlink = | coauthors = | title = Fundamental Neuroscience, 2nd edition | publisher = | date = 2002 | location = | pages = | url = | doi = | id = | isbn = 0-443-06603-5] Testing with low dose (1/8%) pilocarpine may constrict the tonic pupil due to cholinergic denervation supersensitivity. A normal pupil will not constrict with the dilute dose of pilocarpine. CT scans and MRI scans may be useful in the diagnostic testing of focal hypoactive reflexes.cite web |url= |title= Diagnosis of Adie syndrome | author= |publisher=|accessdate=2008-01-21 |format= |work=]


The usual treatment of a standardised Adie syndrome is to prescribe reading glasses to correct for impairment of the eye(s). Pilocarpine drops may be administered as a treatment as well as a diagnostic measure, and should be applied three times daily. Thoracic sympathectomy is the definitive treatment of diaphoresis, if the condition is not treatable by drug therapy.


Adie's syndrome is not life threatening or disabling. As such, there is no mortality rate relating to the condition, however loss of deep tendon reflexes is permanent and may progress over time.


It most commonly affects younger women and is unilateral in 80% of cases.


External links

* [ Personal experience]
* [ Animation] at

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Adie syndrome — a syndrome consisting of a pathological pupil reaction (tonic pupil) with a myotonic condition on accommodation; the pupil on the affected side contracts (for near vision) and dilates more slowly than the pupil on the opposite side. In direct or… …   Medical dictionary

  • Holmes-Adie syndrome — see Adie s syndrome * * * (hōmzґ aґde) [Sir G.M. Holmes; William John Adie, Australian neurologist in England, 1886–1935] Adie syndrome …   Medical dictionary

  • Holmes-Adie syndrome — see Adie s syndrome …   The new mediacal dictionary

  • Синдром Эйди (Adie'S Syndrome), Синдром Эйдихолмса (Holmes-Adie Syndrome) — поражение зрачков глаз. Часто наблюдается только на одном глазу. При этом замедляется реакция пораженного зрачка на свет и на конвергенцию. Может отсутствовать один или несколько сухожильных рефлексов. Чаще данное заболевание наблюдается у женщин …   Медицинские термины

  • Синдром Эйди-Холмса (Holmes-Adie Syndrome) — см. Синдром Эйди. Источник: Медицинский словарь …   Медицинские термины

  • Adie — may refer to:* Adrienne Camp (born 1981), singer and songwriter * Adie ( The Sword of Truth ), a fictional character in the epic fantasy series The Sword of Truth People with the given name Adie:* Adie Allen (21st century), British actress * Adie …   Wikipedia

  • Adie's syndrome — Ad·ie s syndrome ā dēz or Ad·ie syn·drome dē n a neurologic syndrome that affects esp. women between 20 and 40 and is characterized by an abnormally dilated pupil, absent or diminished light reflexes of the eye, abnormal accommodation, and lack… …   Medical dictionary

  • Adie's syndrome — Holmes Adie syndrome an abnormality of the pupils of the eyes, often affecting only one eye. The affected pupil is dilated and reacts slowly to light; the response on convergence of the eyes is also slow (see tonic pupil). One or more tendon… …   The new mediacal dictionary

  • syndrome — The aggregate of symptoms and signs associated with any morbid process, and constituting together the picture of the disease. SEE ALSO: disease. [G. s., a running together, tumultuous concourse; (in med.) a concurrence of symptoms, fr. syn,… …   Medical dictionary

  • Adie pupil syndrome — Ad·ie pupil, syndrome (aґde) [William John Adie, English neurologist, 1886–1935] see tonic pupil, under pupil, and see under syndrome …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”