- Löffler's syndrome
Löffler's syndrome or Loeffler's syndrome is a
disease in which a certain type ofwhite blood cell called aneosinophil accumulates in thelung in response to a parasitic infection.It was first described in 1932 by
Wilhelm Löffler [Löffler, W. "Zur Differential-Diagnose der Lungenifiltrierungen. I. Frühfiltrate unter besonerer Berücksichtigung der Rückbildungszeiten." Beiträge zum Klinik der Tuberkulose, 1932, 79, 338-367.] [Löffler, W. "Zur Differential-Diagnose der Lungenifiltrierungen. II. Über flüchtige Succedan-Infiltrate (mit Eosinophilie)." Beiträge zum Klinik der Tuberkulose, 1932, 79, 368-382.] [Löffler, W. "Flüchtige Lungeninfiltrate mit Eosinophilia." Klinische Wochjenschrift, Berlin, 1935, 14: 297-299.] in cases ofeosinophilic pneumonia caused by the parasites "Ascaris lumbricoides ", [GPnotebook|463077386] "Strongyloides stercoralis " and thehookworm s "Ancylostoma duodenale " and "Necator americanus ".Although Löffler only described eosinophilic pneumonia in the context of infection, many authors give the term "Löffler's syndrome" to any form of acute onset pulmonary eosinophilia no matter what the underlying cause. Cardiac damage caused by the damaging effects of eosinophil granule proteins (ex.
major basic protein ) is known asLoeffler endocarditis and can be caused by idiopathic eosinophilia or eosinophilia in response to parasitic infection.In the differential diagnosis of wheezing.
See also
*
Eosinophilic pneumonia
*Parasitic pneumonia
*Pneumonia References
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