Intraperitoneal hyperthermic chemoperfusion
- Intraperitoneal hyperthermic chemoperfusion
Intraperitoneal hyperthermic chemoperfusion is a procedure in which a warmed solution containing anti-cancer drugs is infused and circulated in the abdominal cavity for a short period of time (usually 90 minutes). This treatment modality is used in certain advanced stage intraabdominal tumors causing peritoneal dissemination (small metastatic nodules), which otherwise are often considered inoperable. The tumors most often treated with this method are appendix cancer (pseudomyxoma peritonei), colorectal cancer, ovarian cancer and gastric cancer. The heated intraperitoneal chemotherapy is generally used after a procedure called cytoreduction (debulking) which may include the removal of all involved peritoneal areas. These procedures can be 8-10 hours long and carry a significant rate of complications. The chemotherapeutic agents generally used are Mytomycin-C and Cisplatin.
Also known as intra-abdominal hyperthermic chemoperfusion, aka Intraperitoneal Hyperthermic Chemotherapy (IPHC). It is often referred to as Sugarbaker technique after Paul Sugarbaker, developer and foremost advocate of this procedure which is still struggling to be generally accepted as standard.
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