Synzymes are substances with catalytic capabilities. The name synzyme is derived from synthetic
enzyme. Current synzymes consist mainly of organic molecules tailored in such a way that they catalyse certain kinds of reactions. Like enzymes, they bind a transition state of a substrate in an acitve site, and like enzymes they generally obey Michaelis-Menten kinetics.
Derivatised proteins:If [Ru(NH3)5] 3+ is attached to certain
histidineresidues in a myoglobinprotein, myoglobin is no longer a passive oxygen carrier, but gains enzmatic activity of an oxidase. Ascorbic acidis oxidised with molecular oxygen. Antibodiescan act as Enzymes, then named abzymes, if they are selected against transition state analogues. Abzymes have a low KM, meaning that they readily bind a target molecule, but have low Vmax values, indicating a slow reaction rate.
Synzymes from organic molecules:
Cyclodextrinsare cap structures with a hydrophilic exterior but a hydrophobic interior. If pyridoxalis anchored in the interior the cyclodextran shows transaminaseactivity.
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* Diekmann S. et al. Metal-mediated reactions modeled after nature. J Biotechnol. 2002 Apr;90(2):73-94
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