DWB may refer to:
- Deep water blackout, a loss of consciousness caused by cerebral hypoxia on ascending from a deep freedive or breath-hold dive
- Deutsches Wörterbuch, one of the most important dictionaries of the German language
- Dirty White Boys, a vivid and violent novel by American author Stephen Hunter
- Doctor Who Bulletin (now Dreamwatch), a British magazine covering science fiction and fantasy films, books and television programmes
- Dominican Winter Baseball League, a professional baseball league in the Dominican Republic
- Driving While Black, a phrase in the contemporary American vernacular that refers to the criminalization of black drivers
- Médecins Sans Frontières (Doctors Without Borders), a secular humanitarian-aid non-governmental organization
- Deutscher Werkbund (German Work Federation), a German association of artists, architects, designers, and industrialists
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