PBT2

PBT2 is a second-generation 8-hydroxy quinoline analog^[1] developed as a successor to Clioquinol as a potential treatment of Alzheimer's Disease.^[2]

References

1. ^ Adlard, Paul A.; Cherny, Robert A.; Finkelstein, David I.; Gautier, Elisabeth; Robb, Elysia; Cortes, Mikhalina; Volitakis, Irene; Liu, Xiang et al. (2008). "Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs is Associated with Decreased Interstitial Aβ". Neuron 59 (1): 43–55. doi:10.1016/j.neuron.2008.06.018. PMID 18614028. 
2. ^ Duce, James A.; Tsatsanis, Andrew; Cater, Michael A.; James, Simon A.; Robb, Elysia; Wikhe, Krutika; Leong, Su Ling; Perez, Keyla et al. (2010). "Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein is Inhibited by Zinc in Alzheimer's Disease". Cell 142 (6): 857–67. doi:10.1016/j.cell.2010.08.014. PMC 2943017. PMID 20817278. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2943017. Lay summary – ScienceDaily (September 10, 2010).