Omega-atracotoxin

Omega-atracotoxin
Identifiers
Symbol	Omega-toxin
Pfam	PF06357
InterPro	IPR009415
SCOP	1hvw
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Omega-atracotoxin is an insect-specific neurotoxin of Blue mountains funnel-web spiders whose phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal amino acid residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels.^[1]

References

1. ^ King GF, Fletcher JI, Tedford HW (2001). "Functional significance of the beta hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a". J. Biol. Chem. 276 (28): 26568–26576. doi:10.1074/jbc.M102199200. PMID 11313356. 

This article includes text from the public domain Pfam and InterPro IPR009415

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