Omega-atracotoxin

Omega-atracotoxin
Identifiers
Symbol	Omega-toxin
Pfam	PF06357
InterPro	IPR009415
SCOP	1hvw
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Omega-atracotoxin is an insect-specific neurotoxin of Blue mountains funnel-web spiders whose phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal amino acid residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels.^[1]

References

1. ^ King GF, Fletcher JI, Tedford HW (2001). "Functional significance of the beta hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a". J. Biol. Chem. 276 (28): 26568–26576. doi:10.1074/jbc.M102199200. PMID 11313356. 

This article includes text from the public domain Pfam and InterPro IPR009415

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Protein toxins Protein stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать курсовую Omedu Omega-logic Look at other dictionaries: Spider toxin — Pfam box Symbol = Toxin 9 Name = Spider toxin width = caption = Pfam= PF02819 InterPro= IPR004169 SMART= Prosite = SCOP = 1oav TCDB = OPM family= 120 OPM protein= 1agg PDB=PDB3|1iva :4 48 PDB3|1oaw :4 48 PDB3|1oav :4 48PDB3|1agg :39 83 PDB3|1omb …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”