MRN complex

The MRN complex is heterotrimeric protein complex consisting of Mre11, Rad50 and Nbs1. It is involved in DNA repair in mammals. Nbs1 is referred to as Nibrin.^[1] This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. Its activity includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).^[2]. It appears that as part of its end-processing of DSBs, short single-strand oligonucleotides are produced, which induce activation of Ataxia Telangiectasia-Mutated (ATM),^[3] ultimately leading to activation of the DNA damage checkpoint.

References

1. ^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology - NBS1". http://atlasgeneticsoncology.org//Genes/NBS1ID160.html. Retrieved 2008-02-12. 
2. ^ "eMedicine - Nijmegen Breakage Syndrome". http://www.emedicine.com/DERM/topic725.htm. Retrieved 2008-02-12. 
3. ^ Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V (2008). "Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity". The EMBO Journal 27 (14): 1953–1962. doi:10.1038/emboj.2008.128. PMID 18596698. http://www.nature.com/emboj/journal/v27/n14/pdf/emboj2008128a.pdf. 

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