Motilin family

Motilin/ghrelin
Structure of motilin in isotropic phospholipid bicellar solution.[1]
Identifiers
Symbol	Motilin_ghrelin
Pfam	PF04644
InterPro	IPR006738
SCOP	1lbj
OPM family	154
OPM protein	1lbj
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. It is released into the general circulation at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions. Motilin also stimulates endogenous release of the endocrine pancreas^[2].

This domain is also found in ghrelin, a growth hormone secretagogue synthesised by endocrine cells in the stomach. Ghrelin stimulates growth hormone secretagogue receptors in the pituitary. These receptors are distinct from the growth hormone-releasing hormone receptors, and thus provide a means of controlling pituitary growth hormone release by the gastrointestinal system^[3].

Human proteins

GHRL; MLN;

References

1. ^ Andersson A, Mäler L (October 2002). "NMR solution structure and dynamics of motilin in isotropic phospholipid bicellar solution". J. Biomol. NMR 24 (2): 103–12. doi:10.1023/A:1020902915969. PMID 12495026. 
2. ^ Itoh Z (1997). "Motilin and clinical application". Peptides 18 (4): 593–608. doi:10.1016/S0196-9781(96)00333-6. PMID 9210180. 
3. ^ Kangawa K, Matsuo H, Kojima M, Hosoda H (2001). "Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor". Trends Endocrinol. Metab. 12 (3): 118–122. doi:10.1016/S1043-2760(00)00362-3. PMID 11306336. 

This article includes text from the public domain Pfam and InterPro IPR006737