DsbC protein family

Disulfide bond isomerase protein N-terminus
x-ray structure of dsbc from haemophilus influenzae
Identifiers
Symbol	DsbC_N
Pfam	PF10411
InterPro	IPR018950
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

In molecular biology, the DsbC protein family is a family of prokaryotic disulfide bond isomerases. This family includes DsbC. DsbC is V-shaped, where each arm is a DsbC monomer of two domains linked by a hinge; and the N-termini of each monomer join to form the dimer interface at the base of the V, so are vital for dimerisation.^[1] DsbC is required for disulfide bond formation and functions as a disulfide bond isomerase during oxidative protein-folding in bacterial periplasm. It also has chaperone activity.^[2]

References

1. ^ McCarthy AA, Haebel PW, Torronen A, Rybin V, Baker EN, Metcalf P (March 2000). "Crystal structure of the protein disulfide bond isomerase, DsbC, from Escherichia coli". Nat. Struct. Biol. 7 (3): 196–9. doi:10.1038/73295. PMID 10700276. 
2. ^ Hiniker A, Collet JF, Bardwell JC (October 2005). "Copper stress causes an in vivo requirement for the Escherichia coli disulfide isomerase DsbC". J. Biol. Chem. 280 (40): 33785–91. doi:10.1074/jbc.M505742200. PMID 16087673. 

This article includes text from the public domain Pfam and InterPro IPR018950