Dictyoglomi-1 RNA motif

Dictyoglomi-1 RNA
Consensus secondary structure of Dictyoglomi-1 RNAs. This figure is adapted from a previous publication.[1]
Identifiers
Symbol	Dictyoglomi-1
Rfam	RF01703
Other data
RNA type	Gene; sRNA;
Domain(s)	Bacteria;
SO	0000655

The Dictyoglomi-1 RNA motif (also called dct-1) is a conserved RNA structure that was discovered via bioinformatics.^[1][2] Only four instances of the RNA were detected, and all are in the bacterial phylum Dictyoglomi, whose members have not been extensively studied. The RNA might have a cis-regulatory role, but the evidence is ambiguous. Because of the few instances of Dictyoglomi-1 RNAs known, it is also unknown whether the RNA structure might extend further in the 5′ or 3′ direction, or in both directions.

The Dictyoglomi-1 RNA motif conserves four bulged-G modules^[3][4] (also called E-loops) Bulged-G modules are often associated with intermolecular interactions, and multiple examples are found in ribosomal RNAs. However the biological role that the four bulged-G modules play in the context of Dictyoglomi-1 RNAs remains unknown.

References

1. ^ ^{a b} Weinberg Z, Wang JX, Bogue J, et al. (March 2010). "Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea and their metagenomes". Genome Biol 11 (3): R31. doi:10.1186/gb-2010-11-3-r31. PMC 2864571. PMID 20230605. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2864571. 
2. ^ Weinberg Z, Perreault J, Meyer MM, Breaker RR (December 2009). "Exceptional structured noncoding RNAs revealed by bacterial metagenome analysis". Nature 462 (7273): 656–9. doi:10.1038/nature08586. PMID 19956260. 
3. ^ Westhof E (2010). "The amazing world of bacterial structured RNAs". Genome Biol 11: 108. doi:10.1186/gb-2010-11-3-108. PMC 2864558. PMID 20236470. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2864558. 
4. ^ Lee, JC (2003). Structural studies of ribosomal RNA based on cross-analysis of comparative models and three-dimensional crystal structures (PhD thesis). University of Texas. 

External links

• Rfam page for Dictyoglomi-1 RNA