Daniel Kraft

Daniel Kraft
Daniel Kraft

Daniel Kraft, M.D. is an NIH funded faculty member affiliated with Stanford. He was on clinical faculty with the UCSF pediatric bone marrow transplantation service[1] and serves as the medicine track chair for Singularity University where he is also executive director for the FutureMed executive program.[2]

Daniel is the founder of StemCor Systems and founder and consulting chief medical officer for RegenMed Systems,[3] a clinical-stage medical device company that develops tools to enable regenerative stem cell therapies. He is the inventor of the MarrowMiner, a minimally invasive device for the harvest of bone marrow derived stem and progenitor cells. This device is being commercialized by Hospira Inc. for use in bone marrow transplantation and by RegenMed Systems for use in regenerative medicine.

Dr. Kraft received a degree in Biochemistry from Brown University and his M.D. from the Stanford University School of Medicine. He completed the Harvard combined residency in Internal Medicine and Pediatrics at the Massachusetts General Hospital and the Boston Children's Hospital, before returning to Stanford for clinical fellowship training in hematology/oncology and bone marrow transplantation and a post-doctoral fellowship with Dr. Irving Weissman. Dr. Kraft is board certified in both Pediatrics and Internal Medicine.

In addition to his research and scientific papers, Dr. Kraft has spoken publicly on, performed research into, and consulted on: health data, health statistics, personalized medicine, heath decision making, the future of medicine, and emerging medical technologies.

Contents

Research Profile

As part of his early research at the National Institutes of Health, Dr. Kraft conceived of and demonstrated proof of concept for a monoclonal antibody-based therapy for treating allergic disease; his general approach was later translated to an antibody Xolair therapeutic by Genentech. As a Howard Hughes Medical Institute medical student research fellow at Stanford, he discovered at novel population of developing T-cells, which play a role in HIV infection. His research focuses extensively on stem cell biology, immunology, and regenerative medicine.

Dr. Kraft's research focuses on: stem cell biology and regenerative medicine, stem cell derived immunotherapies for cancer, bioengineering, the hematopoietic stem cell niche in murine and human systems, human T-cell differentiation, and humanized animal models. Dr. Kraft's clinical work focuses on: bone marrow / hematopoietic Stem cell transplantation for malignant and non-malignant diseases in adults & children, medical devices to enable stem cell based regenerative medicine, including marrow derived stem cell harvesting, processing and delivery.

Dr. Kraft built the first Internet-based alphanumeric paging system at the Stanford hospitals to facilitate communication between clinical staff, and later for elements of Stanford internal medicine and bone marrow transplant service.[4]

In addition to his research at and in connection with Stanford University, Dr. Kraft has performed research into and consulting on health data, health statistics, personalized medicine and heath decision making, including work as an adviser to CollabRx (personalized oncology), Wellsphere (health and wellness) (acquired by HealthCentral), Cepheid (point of care diagnostics), and to the X-Prize Foundation.

Scientific Papers

Daniel Kraft has scientific publications to his credit, including several in Science and Nature.[5] He has lectured extensively on stem cell biology and regenerative medicine, and has authored several book chapters.

Publications include the following articles: Endochondral ossification is required for haematopoietic stem-cell niche formation,[6] Scientific Paper: Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches,[7] Functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction,[8] Efficacy of a Novel, Minimally Invasive Bone Marrow Harvesting Device in Pre-Clinical Evaluation and First Human Use,[9] Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction,[10] Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease,[11] Hematopoietic Stem Cells- Basic Science and Clinical Applications,[12] Detection and characterization of cellular immune responses using peptide-MHC microarrays,[13] Venoconstrictive thigh cuffs impede fluid shifts during simulated microgravity,[14] HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo,[15] Differentiation of CD3-4-8- human fetal thymocytes in vivo: characterization of a CD3-4+8- intermediate,[16] and Inhibition of allergic reactions with monoclonal antibody to the high affinity IgE receptor.[17]

Aerospace Medicine

Dr. Kraft has research and clinical expertise in aerospace medicine.

He is a Major in the Air National Guard and serves as flight surgeon, originally with an F-15 squadron in the Massachusetts Air National Guard and currently with an F-16 squadron in the 144th Fighter Wing, California Air National Guard, with whom he has deployed to Nicaragua and Saudi Arabia.[18]

Dr. Kraft is a graduate of the International Space University. Additionally, he has published physiological research at NASA-Ames and JSC, and was a finalist for astronaut selection.

Public Talks

Dr. Kraft has presented talks at a number of venues which have been recorded and are available online including two TEDTalks. Dr. Kraft's talks include presentations at the TED and 2009 & 2011 TEDMED conferences, Singularity University, the Web 2.0 summit, and the 2009 Keynote Address at the USC Body Computing Conference.

Talks and panel discussions include: "TEDTalk - Medicine's Future",[19] "Hype, Hope & Reality in Stem Cells and Regenerative Medicine",[20] "The Future of Medicine",[21] "The Future of Health",[22] and "The Convergence of Life Sciences, Medicine and Exponentially Advancing Life Technologies." [23] and a TED presentation on the Marrow Miner, a minimally invasive bone marrow and adult stem cell harvesting device invented by Dr. Kraft.[24]

Advisory Positions

Other Appointments

While a resident at Harvard, Dr. Kraft founded, developed, and operated the Online Medical Bookstore (later acquired by Netivation), one of the first online marketplaces for medical students and professionals.

Dr. Kraft is a founder of StemCor Systems.[30]

Dr. Kraft serves as faculty track chair for Medicine & Neuroscience at Singularity University.[31]

Honors

  • Adaptive Business Leaders 2011 "Leadership in Innovation" Awardee & Keynote speaker: [32]
  • Young Investigator Award, American Society for Bone Marrow Transplantation (ASBMT) (2008)
  • Research Award, Hope Street Kids Foundation (2006)
  • Clinical Scientist Developmental Award (K-08), NHLBI/NIH (2005)
  • Astronaut selection finalist (Mission Specialist), NASA (2004)
  • National Innovation grant: Collegiate Inventors and Innovators Alliance, NCIIA (2003)
  • United States Air Force Meritorious Achievement Medal (2000)
  • Research Fellowship, Pediatric Scientist Development Program (PSDP)
  • Innovation Grant, National Collegiate Inventors & Innovators Alliance (NCIIA)
  • Dean's Award for Research, Stanford Medical School
  • HHMI Research Training Fellowship, Howard Hughes Medical Institute

References

  1. ^ Stanford School of Medicine, [http://med.stanford.edu/
  2. ^ FutureMed Executive Program
  3. ^ RegenMed Systems
  4. ^ [Longhurst C. , Kraft D. Internet-Based Alphanumeric Paging: A Useful Tool for Rapid, Convenient and Effective Intrahospital Communication. American Acad of Pediatrics 2002 National Conference & Exhibition. 2002: Abstract 1:707]
  5. ^ Publication List
  6. ^ Scientific Paper: Endochondral ossification is required for haematopoietic stem-cell niche formation
  7. ^ Scientific Paper: Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches
  8. ^ Scientific Paper: Functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction
  9. ^ Efficacy of a Novel, Minimally Invasive Bone Marrow Harvesting Device in Pre-Clinical Evaluation and First Human Use
  10. ^ Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction
  11. ^ Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease
  12. ^ Hematopoietic Stem Cells- Basic Science and Clinical Applications
  13. ^ Detection and characterization of cellular immune responses using peptide-MHC microarrays
  14. ^ Venoconstrictive thigh cuffs impede fluid shifts during simulated microgravity
  15. ^ HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo
  16. ^ Differentiation of CD3-4-8- human fetal thymocytes in vivo: characterization of a CD3-4+8- intermediate
  17. ^ Inhibition of allergic reactions with monoclonal antibody to the high affinity IgE receptor
  18. ^ Stanford Report: High-flying fellow divides his time between stem cell research and guard duties as a flight surgeon
  19. ^ TEDTalk: Medicine's Future...
  20. ^ TEDMED Talk: Hype, Hope & Reality in Stem Cells and Regenerative Medicine
  21. ^ Singularity University Talk: The Future of Medicine
  22. ^ Web 2.0 Summit Panel: The Future of Health (With Marc Hodosh, Anne Wojcicki, Carol McCall, and Daniel Kraft
  23. ^ Keynote Address, USC Body Computing Conference: The Convergence of Life Sciences, Medicine and Exponentially Advancing Life Technologies
  24. ^ TED Presentation on the 'MarrowMiner' bone marrow extraction device
  25. ^ X Prize Foundation Website
  26. ^ CollabRx Website
  27. ^ Wellsphere Website
  28. ^ Cephid Website
  29. ^ Lunar Design Website
  30. ^ Quicker Bone Marrow Harvest with "MarrowMiner" device
  31. ^ Singularity University
  32. ^ Adaptive Business Leaders “Leadership in Innovation"

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