- Podosome
Podosomes are the primary sites of
integrin stimulatedactin polymerization inleukocytes of the monocytic lineage. B cells have also been reported to form podosomes. Podosomes are similar in composition and structure to theinvadopodia found infibroblasts transformed with thev-Src oncogene which are matrix-degrading and whose formation is associated with increasedtumor cell invasiveness. [cite journal |author=Linder S |title=The matrix corroded: podosomes and invadopodia in extracellular matrix degradation |journal=Trends Cell Biol. |volume=17 |issue=3 |pages=107–17 |year=2007 |month=March |pmid=17275303 |doi=10.1016/j.tcb.2007.01.002]In
myeloid cells, podosomes are necessary for directional movement and trans-cellulardiapedesis at sites of inflammation. [cite journal |author=Calle Y, Burns S, Thrasher AJ, Jones GE |title=The leukocyte podosome |journal=Eur. J. Cell Biol. |volume=85 |issue=3-4 |pages=151–7 |year=2006 |month=April |pmid=16546557 |doi=10.1016/j.ejcb.2005.09.003 ] Inosteoclasts , podosomes are thought to aid in the creation of sealing rings associated with the area ofbone resorption .Unlike focal contacts in fibroblasts and
epithelial cells , the formation of podosomes does not require protein synthesis.ee also
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Lamellipodia References
External links
* [http://topics.scirus.com/Podosomes_and_Invadopodia.html Podosomes and Invadopodia] at Scirus Topic Pages
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