Chitinase A N-terminal domain

Chitinase A N-terminal domain
PDB 1edq EBI.jpg
crystal structure of chitinase a from s. marcescens at 1.55 angstroms
Symbol ChitinaseA_N
Pfam PF08329
Pfam clan CL0159
InterPro IPR013540
SCOP 1ctn

In molecular biology, the chitinase A N-terminal domain is found at the N-terminus of a number of bacterial chitinases and similar viral proteins. It is organised into a fibronectin III module domain-like fold, comprising only beta strands. Its function is not known, but it may be involved in interaction with the enzyme substrate, chitin.[1][2] It is separated by a hinge region from the catalytic domain; this hinge region is probably mobile, allowing the N-terminal domain to have different relative positions in solution.[1]


  1. ^ a b Perrakis A, Tews I, Dauter Z, Oppenheim AB, Chet I, Wilson KS, Vorgias CE (December 1994). "Crystal structure of a bacterial chitinase at 2.3 A resolution". Structure 2 (12): 1169–80. PMID 7704527. 
  2. ^ Perrakis A, Ouzounis C, Wilson KS (1997). "Evolution of immunoglobulin-like modules in chitinases: their structural flexibility and functional implications". Fold Des 2 (5): 291–4. PMID 9377712. 

This article includes text from the public domain Pfam and InterPro IPR013540

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