ChiRP-Seq

ChIRP-Seq is a high-throughput sequencing method to discover RNA-bound DNA and proteins. The RNA sequences of interest are hybridized to oligonucleotide tiles using biotin/streptavidin. The chromatin fraction that is bound to the beads is then determined using high-throughput sequencing.^[1]

References

1. ^ Chu, Ci; Qu, Kun, Zhong, Franklin L., Artandi, Steven E., Chang, Howard Y. (31 August 2011). "Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions". Molecular Cell. doi:10.1016/j.molcel.2011.08.027.