- 1,4,6-androstatrien-3,17-dione (ATD)
drugbox
IUPAC_name = 1,4,6-androstatriene-3,17-dione
width = 177
CAS_number=633-35-2
ATC_prefix=
ATC_suffix=
ATC_supplemental=
PubChem=
DrugBank=
C=19 | H=22 | O=2
molecular_weight = 282.38
bioavailability=
metabolism =
elimination_half-life=
excretion = Urinary:?%
pregnancy_category =
legal_status = Commercially available
(US)
routes_of_administration= Oral
melting_point = 1641,4,6-androstatriene-3,17-dione (ATD) is a steroidal aromatase inhibitor sold over the counter in the US as a dietary supplement. [Brodie AM, Brodie HJ, Garrett WM, Hendrickson JR, Marsh DA, Tsai-Morris CH. (1982). Effect of an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione, on 7,12-dimethylbenz [a] anthracene-induced mammary tumors in the rat and its mechanism of action in vivo. Biochem Pharmacol. 31(11): 2017-23.] [Covey DF, Hood WF. (1981). Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity. Endocrinology. 108(4): 1597-9.]
References
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