Missouri Route 53

Route 53
Route information
Maintained by MoDOT
Length:	33 mi (53 km)
Existed:	1922 – present
Major junctions
From:	Route 25 in Holcomb
North direction_a = South end:	Business U.S. Route 67/U.S. Route 160 in Poplar Bluff
Highway system
Missouri Highways Supplemental ← Route 52 US 54 →

Route 53 is a highway in southeastern Missouri. Its northern terminus is at Business U.S. Route 67/U.S. Route 160 in Poplar Bluff. Its southern terminus is at Route 25 in Holcomb.

Route 53 is one of the original state highways and has remained essentially unchanged since 1922.