Rs4680

Infobox Single nucleotide polymorphism
rsid = 4680
name_1 = Val158Met
name_2 = Val108/158Met
name_3 = G1947A
gene = COMT
chromosome = 22
region = Exon 3
alzgene_geneid = 227
alzgene_polyid = 644
szgene_geneid = 420
szgene_polyid = 2954In genetics, rs4680 (Val158Met) is a genetic variant.It is a single nucleotide polymorphism (SNP) in the "COMT" gene that codes catechol-"O"-Methyltransferase.The single nucleotide substitution between G and A results in a amino acid change from valine to methionine at codon 158.

Research studies have show that the valine allele is related to higher "COMT" activity.

Several personality genetics studies have examined the association of the polymorphism with personality traits. [Cite journal
author = Martin Reuter & Juergen Hennig
title = Association of the functional catechol-O-methyltransferase VAL158MET polymorphism with the personality trait of extraversion
journal = NeuroReport
volume = 16
issue = 10
pages = 1135–1138
year = 2005
month = July
pmid = 15973162] [Cite journal
author = Se Joo Kim, Young Shin Kim, Shin Young Kim, Hong Shick Lee & Chan-Hyung Kim
title = An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans
journal = Neuroscience Letters
volume = 401
issue = 1-2
pages = 154–158
year = 2006
month = June
doi = 10.1016/j.neulet.2006.03.006
pmid = 16584839] [Cite journal
author = Ryota Hashimoto, Hiroko Noguchi, Hiroaki Hori, Kazutaka Ohi, Yuka Yasuda, Masatoshi Takeda & Hiroshi Kunugi
title = A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects
journal = Neuroscience Letters
volume = 428
issue = 1
pages = 17–10
year = 2007
month = November
doi = 10.1016/j.neulet.2007.09.036
pmid = 17945417] [Cite journal
author = Murray B. Stein, Margaret Daniele Fallin, Nicholas J. Schork & Joel Gelernter
title = COMT polymorphisms and anxiety-related personality traits
journal = Neuropsychopharmacology
volume = 30
issue = 11
pages = 2092–2092
year = 2005
month = November
doi = 10.1038/sj.npp.1300787
pmid = 15956988]

References