Rs5569

Infobox Single nucleotide polymorphism
rsid = 5569
name_1 = A1287G
name_2 = G1287A
gene = SLC6A2
region = Exon 9In genetics, rs5569 (A1287G or G1287A) is a genetic variant. It is a single nucleotide polymorphism (SNP) in the "SLC6A2" gene in exon 9.This gene codes the norepinephrine transporter. The SNP is a silent substitution andthe nucleotides of both variants code a threonine amino acid. [ [http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?chooseRs=het&locusId=6530&mrna=NM_001043.2&ctg=NT_010498.15&prot=NP_001034.1&orien=forward&refresh=refresh dbSNP] ]

Several research studies have examined the effect of the variant in relation to alcohol dependence, [Cite journal
author = Jerzy Samochowiec, Jolanta Kucharska-Mazur, Ryszard Kaminski, Michael Smolka, Hans Rommelschpacher, Catrin Wernicke, Agnieszka Tymicz & Lutz Gerhardt Schmidt
title = Norepinephrine transporter gene polymorphism is not associated with susceptibility to alcohol dependence
journal = Psychiatry Research
volume = 111
issue = 2-3
pages = 229–223
year = 2002
month = August
pmid = 12374639] [Cite journal
author = San-Yuan Huang, Ru-Band Lu, Kuo-Hsing Ma, Mee-Jen Shy & Wei-Wen Lin
title = Norepinephrine transporter polymorphisms T-182C and G1287A are not associated with alcohol dependence and its clinical subgroups
journal = Drug and Alcohol Dependence
volume = 92
issue = 1-3
pages = 20–26
year = 2008
month = January
doi = 10.1016/j.drugalcdep.2007.06.003
pmid = 17630229]
attention deficit hyperactivity disorder, [Cite journal
author = Soo-Churl Cho, Jae-Won Kim, Boong-Nyun Kim, Jun-Won Hwang, Mira Park, Soon Ae Kim, Dae-Yeon Cho, Hee-Jeong Yoo, Un-Sun Chung, Jung-Woo Son & Tae-Won Park
title = No evidence of an association between norepinephrine transporter gene polymorphisms and attention deficit hyperactivity disorder: a family-based and case-control association study in a Korean sample
journal = Neuropsychobiology
volume = 57
issue = 3
pages = 131–138
year = 2008
month =
doi = 10.1159/000138916
pmid = 18552510]
diabetes, [Cite journal
author = Piotr Ksiazek, Kinga Buraczynska & Monika Buraczynska
title = Norepinephrine transporter gene (NET) polymorphism in patients with type 2 diabetes
journal = Kidney & blood pressure research
volume = 29
issue = 6
pages = 338–333
year = 2006
month =
doi = 10.1159/000097356
pmid = 17124432]
major depressive disorder, [Cite journal
author = Peter Zill, Rolf Engel, Thomas C. Baghai, Georg Juckel, Thomas Frodl, Florian Muller-Siecheneder, Peter Zwanzger, Cornelius Schule, Christo Minov, Stefanie Behrens, Rainer Rupprecht, Ulrich Hegerl, Hans Jurgen Moller & Brigitta Bondy
title = Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression
journal = Neuropsychopharmacology
volume = 26
issue = 4
pages = 489–483
year = 2002
month = April
doi = 10.1016/S0893-133X(01)00386-4
pmid = 11927173] [Cite journal
author = Kazuyuki Inoue, Kunihiko Itoh, Keizo Yoshida, Hisashi Higuchi, Mitsuhiro Kamata, Hitoshi Takahashi, Tetsuo Shimizu & Toshio Suzuki
title = No association of the G1287A polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a Japanese population
journal = Biological & Pharmaceutical Bulletin
volume = 30
issue = 10
pages = 1996–1998
year = 2007
month = October
pmid = 17917281]
panic disorder, [Cite journal
author = P. G. Sand, T. Mori, C. Godau, G. Stober, P. Flachenecker, P. Franke, M. M. Nothen, J. Fritze, W. Maier, K.-P. Lesch, P. Riederer, H. Beckmann & J. Deckert
title = Norepinephrine transporter gene (NET) variants in patients with panic disorder
journal = Neuroscience Letters
volume = 333
issue = 1
pages = 41–44
year = 2002
month = November
pmid = 12401556]
Tourette syndrome [Cite journal
author = Christopher A. Rippel, Andrew J. Kobets, Dustin Y. Yoon, Phillip N. Williams, Yin Yao Shugart, Dana D. Bridges, David J. Vandenbergh & Harvey S. Singer
title = Norepinephrine transporter polymorphisms in Tourette syndrome with and without attention deficit hyperactivity disorder: no evidence for significant association
journal = Psychiatric Genetics
volume = 16
issue = 5
pages = 179–170
year = 2006
month = October
doi = 10.1097/01.ypg.0000218622.96127.71
pmid = 16969268] and personality traits. [Cite journal
author = J. Samochowiec, F. Rybakowski, P. Czerski, M. Zakrzewska, G. Stepien, J. Pelka-Wysiecka, J. Horodnicki, J. K. Rybakowski & J. Hauser
title = Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers
journal = Neuropsychobiology
volume = 43
issue = 4
pages = 248–243
year = 2001
month =
pmid = 11340364] None of the studies have found an association.

References

Further reading

* Cite journal
author = E. G. Jonsson, M. M. Nothen, J. P. Gustavsson, H. Neidt, R. Bunzel, P. Propping & G. C. Sedvall
title = Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationships to monoamine metabolite concentrations in CSF of healthy volunteers
journal = Psychiatry Research
volume = 79
issue = 1
pages = 1–9
year = 1998
month = June
pmid = 9676821
* [http://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC6A2&search=neurodegenerative%20or%20senile&suff=txt&snp_show_mode=1&snp=224 GeneCards]