Cryptic splic site

cryptic splice sites

There are four sequence elements within introns of mammalian pre-mRNAs which are required for efficient splicing. These are the conserved sequence at the 5' splice junction, the invariant AG dinucleotide at the 3' splice junction, a weakly conserved sequence at the site of lariat formation etc..Cryptic splice sites are also such kind of motif that are present in many regions throughout pre-mRNAs and yet are not recognized under normal conditions,whereas in transcripts bearing point mutations or deletions within natural elements,such sites can be activated [Selection of Splice Sites in Pre-mRNAs with Short Internal Exons.MOLECULAR AND CELLULAR BIOLOGY, Dec. 1991, p. 6075-6083] .

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