FKBPL

protein
Name=FK506 binding protein like
caption=


width=
HGNCid=13949
Symbol=FKBPL
AltSymbols=DIR1, NG7
EntrezGene=63943
OMIM=
RefSeq= NM_022110
UniProt= Q9UIM3
PDB=
ECnumber=
Chromosome=6
Arm=p
Band=21.3
LocusSupplementaryData=

FK506-binding protein like, also known as FKBPL is a human gene.cite journal | author = Robson TA, Lohrer H, Bailie JR, Hirst DG, Joiner MC, Arrand JE | title = Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line | journal = Biochem. Soc. Trans. | volume = 25 | issue = 1 | pages = 335–42 | year = 1997 | month = February | pmid = 9056895 | doi = | url = | issn = ]

The protein encoded by this gene is involved in cellular response to stress. It was first isolated in 1999 and was initially named DIR1.cite journal | author = Robson T, Joiner MC, Wilson GD, McCullough W, Price ME, Logan I, Jones H, McKeown SR, Hirst DG | title = A novel human stress response-related gene with a potential role in induced radioresistance | journal = Radiat. Res. | volume = 152 | issue = 5 | pages = 451–61 | year = 1999 | month = November | pmid = 10521921 | doi = | url = | issn = ] It was later reclassified because of its homology to the FKBP family of proteins and was renamed FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised p21 termed it Wisp39.cite journal | author =Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A | title = Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein | journal = Mol. Cell | volume = 17 | issue = 2 | pages = 237–49 | year = 2005 | month = January | pmid = 15664193 | doi = 10.1016/j.molcel.2004.11.049 | url = | issn = ]

It is known to interact with with Hsp90, glucocorticoid receptor and dynamitin and may play a role in signalling, like other FKBPs.cite journal | author = McKeen HD, McAlpine K, Valentine A, Quinn DJ, McClelland K, Byrne C, O'Rourke M, Young S, Scott CJ, McCarthy HO, Hirst DG, Robson T | title = A novel FK506-like binding protein (FKBPL) interacts with the glucocorticoid receptor and regulates steroid receptor signalling | journal = Endocrinology | volume = | issue = | pages = | year = 2008 | month = July | pmid = 18669603 | doi = 10.1210/en.2008-0168 | url = | issn = ]

References