Hirano body

Hirano body

Hirano bodies are intracellular aggregates of actin and actin-associated proteins observed in the neurons (nerve cells) of individuals afflicted with certain neurodegenerative disorders, such as Alzheimer's disease and Creutzfeldt-Jakob disease. They are often described as rod-shaped, crystal-like, and eosinophilic (pink after staining with haematoxylin and eosin). They are frequently seen in hippocampal pyramidal cells. [cite book |author=Ramzi Cotran, Vinay Kumar, Tucker Collins |title=Robbins Pathologic Basis of Disease, Sixth Edition |year=1999 |publisher=W.B. Saunders |isbn=072167335X] An experimental model of Hirano body formation has been reported, using a genetically altered strain of the slime mold "Dictyostelium discoideum". [cite journal |author=Maselli AG, Davis R, Furukawa R, Fechheimer M |title=Formation of Hirano bodies in Dictyostelium and mammalian cells induced by expression of a modified form of an actin-crosslinking protein |journal=J. Cell. Sci. |volume=115 |issue=Pt 9 |pages=1939–49 |year=2002 |pmid=11956325 |doi=]

External links

* [http://www.bms.ed.ac.uk/research/others/smaciver/Cyto-Topics/hirano_bodies.htm Hirano Bodies]
* [http://www.whonamedit.com/synd.cfm/3582.html Hirano bodies by "Who named it?"]
* [http://www.uga.edu/aboutUGA/research-slime.html How a Slime Mold Came to the Aid of Alzheimer's Research]

References


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