ELMO3

protein
Name = engulfment and cell motility 3
caption =


width =
HGNCid = 17289
Symbol = ELMO3
AltSymbols = CED12, FLJ13824
EntrezGene = 79767
OMIM = 606422
RefSeq = NM_024712
UniProt = Q96BJ8
PDB =
ECnumber =
Chromosome = 16
Arm = q
Band = 22.1
LocusSupplementaryData =

Engulfment and cell motility 3, also known as ELMO3, is a human gene.cite web | title = Entrez Gene: ELMO3 engulfment and cell motility 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79767 | accessdate = ] cite journal | author = Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS | title = CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration | journal = Cell | volume = 107 | issue = 1 | pages = 27–41 | year = 2001 | month = October | pmid = 11595183 | doi = 10.1016/S0092-8674(01)00520-7 | url = | issn = ]

The protein encoded by this gene is similar to a "C. elegans" protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 (DOCK1) protein to promote phagocytosis and effect cell shape changes.

References

External links

*