Gag/pol translational readthrough site

Gag/pol translational readthrough site is a cis-regulatory element found in retroviruses cite journal |author=Wills NM, Gesteland RF, Atkins JF |title=Pseudoknot-dependent read-through of retroviral gag termination codons: importance of sequences in the spacer and loop 2 |journal=EMBO J. |volume=13 |issue=17 |pages=4137–44 |year=1994 |month=September |pmid=8076609 |pmc=395336 |doi= |url=] . Retroviruses whose gag and pol genes are in the same reading frame often depend upon approximately 5% read-through of the gag UAG termination codon to form the gag-pol polyprotein. This readthrough is usually dependent on a pseudoknot located eight nucleotides downstream of the stop codon (UAG). Sequence conservation is found in the second pseudoknot loop.

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Retroviral readthrough element