- InnoMed PredTox
Research-Project
name=InnoMed PredTox
title=Innovative Medicines for Europe - Predictive Toxicology
keywords=Toxicogenomics ,Drug development ,Pre-clinical development
fundingAgency=European Commission
frameworkProgramme=FP6
projectType=Integrated Project
researchObjective=Assess the value of combining results from omics technologies together with the results from more conventional toxicology methods for more informed decision making in preclinical safety evaluation
projectReference=FP6-518170
coordinator=EFPIA
participants=EFPIA Companies
Bayer Schering PharmaBoehringer-Ingelheim
Johnson and Johnson
LillyMerck Serono Novartis Novo Nordisk Nycomed
RocheSanofi-Aventis Schering-Plough Servier UniversitiesUniversity of Würzburg University College Dublin Hacettepe University Technology ProvidersBio-Rad Genedata |budget=8 Mio. EUR
funding=
start=1 October 2005
end=31 January 2009
website=http://www.innomed-predtox.comInnoMed PredTox is a joint
Industry andEuropean Commission collaboration to improve drug safety. The consortium is composed of 15 research groups from 12 pharmaceutical companies, three academic institutions and two technology providers.The goal of InnoMed PredTox is to assess the value of combining results from omics technologies together with the results from more conventionaltoxicology methods for more informed decision making in preclinical safety evaluation.The project was initiated in October 2005 with a term of 40 month. It receives funding as an Integrated Project under the
Sixth Framework Programme . The project had been set up jointly by theEuropean Federation of Pharmaceutical Industries and Associations (EFPIA) and theEuropean Commission as a pilot project for the subsequent design of theInnovative Medicines Initiative [IMI website by EFPIA [http://www.imi-europe.org/pilot%20project/pages/default.aspx] ] [European Commission website [http://imi.europa.eu/innomed_en.html] ]As part of the project the partners ran a series of regular 14 days toxicological studies with daily dosing. The compounds had been selected representing compounds with promising drug-like properties but that had been terminated due to toxic effects on the
liver and/or kidneys of rats).The project collected and jointly analysed transcriptomics,
proteomics ,metabonomics and conventional toxicological data on 14 failed drug candidates together with two reference compounds [Mulrane et al., Exp Toxicol Pathol. 2008 Aug;60(4-5):235-45 [http://www.ncbi.nlm.nih.gov/pubmed/18479893] ] ,troglitazone [E. Troesken et al., Application of a Systems Toxicology Approach to Investigate Troglitazone Hepatotoxicity in the Rat, Abstract ID 675, The Toxicologist CD — An official Journal of the Society of Toxicology, Volume 102, Number S-1, March 2008 [http://www.toxicology.org/ai/pub/publications.asp] [http://www.innomed-predtox.com/media__events/publications/index_eng.html (slides)] ] andgentamicin [E. Com et al., Integrated Transcriptomic and Proteomic Evaluation of Gentamicin Nephrotoxicity in Rats, Abstract ID 676, The Toxicologist CD — An official Journal of the Society of Toxicology, Volume 102, Number S-1, March 2008 [http://www.toxicology.org/ai/pub/publications.asp] [http://www.innomed-predtox.com/media__events/publications/index_eng.html (slides)] ] . As data integration across different data areas and technology platforms is considered a prerequisite to building a consistent standardised data schema for joint analysis [A.M. Richard, Chem Res Toxicol. 2006 Oct;19(10):1257-62 [http://www.ncbi.nlm.nih.gov/pubmed/17040094] ] all project data are stored in a database [W.B. Mattes, Methods Mol Biol. 2008;460:221-38. [http://www.ncbi.nlm.nih.gov/pubmed/18449490] ] custom developed byGenedata .Milestones
Status: August 2008
References
See also
*
EFPIA
*Toxicogenomics
*Innovative Medicines Initiative External links
* [http://www.innomed-predtox.com/ InnoMed PredTox] official project website
* [http://www.imi-europe.org/ Innovative Medicines Initiative] -EFPIA website
* [http://imi.europa.eu Innovative Medicines Initiative] -European Commission website
* [http://www.innomed-predtox.com/links/index_eng.html List of Related Projects]
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