IL-34

Interleukin-34, or IL-34 is a newly discovered interleukin. It was found in a massive screen of secreted proteins by Lin et al at Five Prime Therapeutics, a company based on the Mission Bay campus of UCSF. IL-34 increases monocyte viablity and acts through its receptor colony-stimulating factor 1. The protein is 39 kilodaltons in size and forms homodimers.

Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, Halenbeck R, Wu G, Zhou A, Behrens D, Hollenbaugh D, Linnemann T, Qin M, Wong J, Chu K, Doberstein SK, Williams LT. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.Science. 2008 May 9;320(5877):807-11. PMID: 18467591