- Simulations Plus
Infobox_Company
name = Simulations Plus, Inc.
type = Public (NASDAQ|SLP)
foundation =1996 in Lancaster,California
founder = Walter Woltosz
location_city = Lancaster,California
location_country = USA
industry =Software
num_employees = 20
products =Software GastroPlusTM ADMET PredictorTM ClassPharmerTM DDDPlusTM
homepage = [http://www.simulations-plus.com/ www.simulations-plus.com] Tnavbar|Infobox Simulations Plus, Inc.Simulations Plus, Inc. develops absorption, distribution, metabolism, excretion, and toxicity (ADMET) modeling and simulation software for the pharmaceutical and biotechnology industries.
Software programs
The company has produced specific proprietary software products, such as:
* "GastroPlusTM", a physiologically-based simulation tool that predicts the absorption,
pharmacokinetics , andpharmacodynamics for drugs administered intravenously or orally. The modeling theory and approach has been discussed in several peer-reviewed publications [Dannenfelser RM, He H, Joshi Y, Bateman S, Serajuddin AT. Development of clinical dosage forms for a poorly water soluble drug I: Application of polyethylene glycol-polysorbate 80 solid dispersion carrier system. J Pharm Sci. 2004 May;93(5):1165-75.] [Kuentz M, Nick S, Parrott N, Röthlisberger D. A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study. Eur J Pharm Sci. 2006 Jan;27(1):91-9.] [De Buck SS, Sinha VK, Fenu LA, Nijsen MJ, Mackie CE, Gilissen RA. Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs. Drug Metab Dispos. 2007 Oct;35(10):1766-80.] [Tubic-Grozdanis M, Bolger MB, Langguth P. Application of gastrointestinal simulation for extensions for biowaivers of highly permeable compounds. AAPS J. 2008;10(1):213-26.] [Brandl M, Wu X, Holper M, Hong L, Jia Z, Birudaraj R, Reddy M, Alfredson T, Tran T, Larrabee S, Hadig X, Sarma K, Washington C, Hill G, Smith DB. Physicochemical properties of the nucleoside prodrug r1626 leading to high oral bioavailability. Drug Dev Ind Pharm. 2008 Jul;34(7):683-91.] [Okumu A, Dimaso M, Löbenberg R. Dynamic Dissolution Testing To Establish In Vitro/In Vivo Correlations for Montelukast Sodium, a Poorly Soluble Drug. Pharm Res. 2008 Jun 17.] [Allan G, Davis J, Dickins M, Gardner I, Jenkins T, Jones H, Webster R, Westgate H. Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use of in silico physiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in man. Xenobiotica. 2008 Jun;38(6):620-40.] .* "ADMET PredictorTM" a modeling program that enables pharmaceutical researchers to estimate ADMET properties from chemical structure. The performance of the models have been assessed in several peer-reviewed articles [Dearden, J.C.. "In silico prediction of aqueous solubility." Expert Opin. Drug Discov 1(2006): 31-52, 2006.] [Tetko, I. V. and Poda, G. I. "Property-based logP prediction." In: R. Mannhold (ed.), Molecular Drug Properties: Measurement and Prediction, pp. Chapter 15. Weinheim, Germany: Wiley-VCH, 2007.] .
* "ClassPharmerTM", a multi-purpose
cheminformatics software tool used for screening data analysis.* "DDDPlusTM", a software tool for formulation scientists that simulates the "in vitro" disintegration and
dissolution of solid dosage forms under different experimental conditions.As of August 3, 2008, 18 of the top 20 pharmaceutical companies, along with the
U.S. Food and Drug Administration (FDA), theU.S. Environmental Protection Agency (EPA), and theNational Institutes of Health (NIH), license the company's software.References
* [http://topics.nytimes.com/top/news/business/companies/simulations-plus-inc/index.html?scp=1&sq=%22Simulations%20Plus%22&st=cse New York Times - Company Information - Simulations Plus]
* [http://www.alacrastore.com/storecontent/datamonitor-company-profiles/mtx00203 Simulations Plus, Inc. - Datamonitor Company Profiles via Alacra Store - May 23, 2008 ]
Links
*cite news |first= |last= |authorlink= |coauthors= |title=U.S. FDA Licenses GastroPlus(TM). |url=http://www.accessmylibrary.com/coms2/summary_0286-29149329_ITM |work=Business Wire |publisher= |date=09 JAN 2007 |accessdate=2008-08-01
*cite news |first= |last= |authorlink= |coauthors= |title=U.S. EPA Licenses Simulations Plus' ADMET Predictor(TM) Software. |url=http://www.medicalnewstoday.com/articles/111882.php |work=Medical News Today |publisher= |date=19 JUN 2008 |accessdate=2008-08-01
*cite news |first= |last= |authorlink= |coauthors= |title=U.S. National Institutes of Health Licenses Simulations Plus' ClassPharmer(TM) Software. |url=http://findarticles.com/p/articles/mi_m0EIN/is_2007_August_30/ai_n27360002 |work=bNet |publisher= |date=30 AUG 2007 |accessdate=2008-08-01
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