Bruce H. Lipshutz

Bruce H. Lipshutz (born 1951) is an American chemist. He is a professor at the University of California, Santa Barbara. [ Department of Chemistry and Biochemistry, UCSB: People, Faculty [http://www.chem.ucsb.edu/people/faculty/lipshutz/index.shtml] ]

Biography

Bruce Lipshutz received his undergraduate degree in chemistry from SUNY Binghamton in 1973. He did his graduate work under the supervision of Professor Harry H. Wasserman at Yale and obtained a PhD degree in 1977. He spent two years at Harvard as a post-doctoral researcher in the group of Nobel Laureate E. J. Corey. Soon after, he accepted a position of Assistant Professor at UCSB rising to the ranks of Professor in 1987. He has received the Alfred P. Sloan Foundation Fellowship and the Camille & Henry Dreyfus Teacher-Scholar Award. Bruce is Co-founder of Zymes LLC. [ Zymes llc [http://www.zymesllc.com/about/management-team/] ]

Contributions

Reagents

* [http://www.sigmaaldrich.com/catalog/search/ProductDetail/ALDRICH/238902| 2-(Trimethylsilyl)ethoxymethyl chloride] : hydroxyl protecting group, selectively cleaved with fluoride ion under mild conditions. [ β-(Trimethylsilyl)ethoxymethyl chloride. A new reagent for the protection of the hydroxyl group [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6THS-42M7VH1-CX&_user=112642&_coverDate=12%2F31%2F1980&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000059608&_version=1&_urlVersion=0&_userid=112642&md5=281d979f2a9d8fc5ae34fd5005488c7d] ]
* [http://www.sigmaaldrich.com/catalog/search/ProductDetail/ALDRICH/680850| Di-(4-chlorobenzyl)azodicarboxylate (DCAD)] : recyclable and convenient alternative to diethylazodicarboxylate (DEAD) or diisopropyazodicarboxylate (DIAD) in Mitsunobu reaction. [ Simplification of the Mitsunobu Reaction. Di-p-chlorobenzyl Azodicarboxylate: A New Azodicarboxylate [http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2006/8/i22/abs/ol0618757.html] ]
*Ligated copper hydride. [ (BDP)CuH: A "Hot" Stryker's reagent for Use in Achiral Conjugate Reductions [http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2008/10/i02/abs/ol702689v.html] ] [ Asymmetric Hydrosilylation of Aryl Ketones Catalyzed by Copper Hydride Complexed by Nonracemic Biphenyl Bis-phosphine Ligands [http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/2003/125/i29/abs/ja021391f.html] ]
*Heterogeneous catalysts: nickel-on-charcoal, copper-on-charcoal, nickel-in-graphite, copper+nickel-on-charcoal.

Methodologies

*Higher order organocuprates (Lipshutz cuprates).
*Chiral and achiral conjugate reductions.

References