Ecallantide

Ecallantide (investigational name DX-88) is an inhibitor of the protein kallikrein used for hereditary angioedema and in the prevention of blood loss in cardiothoracic surgery.cite journal |author=Lehmann A |title=Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery |journal=Expert Opin Biol Ther |volume=8 |issue=8 |pages=1187–99 |year=2008 |month=August |pmid=18613770 |doi=10.1517/14712598.8.8.1187 |url=] It is a 60-amino acid polypeptide that was shown to inhibit kallikrein in a laboratory investigation known as phage display. Its benefit in cardiothoracic surgery would make it a replacement for aprotinin, which was withdrawn in 2007 after being shown to cause complications.

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