Infobox road
state=Japan
type=National
route=221
maint=
name_notes="国道221号"
length_km=74.6
length_round=
length_ref=
established=
direction_a=
terminus_a=
junction=
direction_b=
terminus_b=
browse=
commons=category
customcommons=Route 221 (Japan)
National Route 221 is a national highway of
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