Howell-Jolly body

Howell-Jolly body

Howell-Jolly bodies are histopathological findings of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow erythrocytes normally expel their nuclei, but in some cases a small portion of DNA remains.

It is named for William Henry Howell and Justin Marie Jolly. [WhoNamedIt|synd|1596] [W. H. Howell. The life-history of the formed elements of the blood, especially the red blood corpuscles. Journal of Morphology, New York, 1890-91, 4: 57-116.] [J. M. J. Jolly. Sur la formation des globules rouges des mammifères. Comptes rendus de la Société de Biologie, Paris, 1905, 58: 528-531.]

Appearance

This DNA appears as a basophilic (purple) spot on the otherwise eosinophilic (pink) erythrocyte on a standard H and E stained blood smear. These inclusions are normally pitted out by the spleen during erythrocyte circulation, but will persist in individuals with functional hyposplenia or asplenia.

Causes

Common causes of asplenia are splenectomy due to trauma, and autosplenectomy caused by sickle cell anemia. Other causes are radiation therapy involving the spleen, such as that used to treat Hodgkin lymphoma. Howell-Jolly bodies are also seen in: Severe hemolytic anemia,
Megaloblastic anemia,
Hereditary spherocytosis
Myelodysplastic syndrome (MDS).

References

External links

* [http://www.healthsystem.virginia.edu/internet/hematology/HessEDD/benignhematologicdisorders/redbloodcelldisorders/howell-jolly-body.cfm Howell-Jolly bodies] : Presented by the University of Virginia
* http://www.academic.marist.edu/~jzmz/topics/inclusions/inclusions18.html
* http://www.brown.edu/Courses/Digital_Path/systemic_path/heme/howelljolly.html


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  • howell-jolly body — zhȯˈlē , ˈjälē noun Usage: usually capitalized H&J Etymology: after William H. Howell died 1945 American physiologist and Justin M. J. Jolly died 1953 French physician : one of the basophilic granules that are probably nuclear fragments, that… …   Useful english dictionary

  • Howell-Jolly bodies — How·ell Jol·ly bodies (houґəl zho leґ) [W.H. Howell; Justin Marie Jules Jolly, French histologist, 1870–1953] see under body …   Medical dictionary

  • body — 1. The head, neck, trunk, and extremities. The human b., consisting of head (caput), neck (collum), trunk (truncus), and limbs (membra). 2. The material part of a human, as distinguished from the …   Medical dictionary

  • Jolly bodies — Jol·ly bodies (zho leґ) [Justin Marie Jules Jolly, French histologist, 1870–1953] Howell Jolly bodies; see under body …   Medical dictionary

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  • William Henry Howell — William Henry Howell, Ph.D., M.D., LL.D., Sc.D. (20 February 1860 ndash; 6 February 1945) was an American physiologist. He pioneered the use of heparin as a blood anti coagulant.William Henry Howell was born in Baltimore, Maryland and graduated… …   Wikipedia

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