Meganuclease I-Sce I

Meganuclease I-Sce I

Meganuclease I-Sce I is a homing endonuclease. It recognises an 18-base pair sequence TAGGGATAACAGGGTAAT and leaves a 4 base pair 3' hydroxyl overhang. It is a rare cutting endonuclease. Statistically an 18-bp sequence will occur once in every 6.9*1010 base pairs or once in 20 human genomes. [ [http://www.neb.com/nebecomm/products/productR0694.asp New England Biolabs site] ]

Source

I-SceI is coded by introns. It is present in the mitochondria of yeast Saccharomyces cerevisiae.

References


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  • Meganuclease I-SceI — Meganuclease I Sce I is a homing endonuclease. It recognises an 18 base pair sequence TAGGGATAACAGGGTAAT and leaves a 4 base pair 3 hydroxyl overhang. It is a rare cutting endonuclease. Statistically an 18 bp sequence will occur once in every… …   Wikipedia

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