Pain wind-up

Pain wind-up

Pain wind-up is a phenomenon where repeated painful stimulation of peripheral nerves at sufficient intensity to stimulate group C nerve fibers leads to progressively increasing electrical response in the corresponding spinal posterior horn neurons. This slow, cumulative effect is partly due to the slow response of NMDA receptors, but may also be linked to sustained release of substance P, a neuropeptide, in the posterior horns.

ee also

*Group C nerve fiber#Central Sensitization
*fibromyalgia

External links

*http://www.myalgia.com/chrpain.htm
*http://courses.washington.edu/conj/sensory/pain.htm


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