Rs7997012

Infobox Single nucleotide polymorphism
rsid = 7997012
gene = HTR2A
chromosome = 13
region = Intron 2In genetics, rs7997012 is a gene variation—a single nucleotide polymorphism (SNP)—in intron 2 of the human HTR2A gene that codes for the 5-HT_2A receptor. The SNP varies between adenine (A) and guanine (G) DNA bases with the G-allele being most frequent. [Cite web
title = SNP report for rs7997012
url = http://www.hapmap.org/cgi-perl/snp_details?name=rs7997012&source=hapmap_B35
publisher = International HapMap Project] A research study found it to be related to antidepressant treatment. [Cite journal
author = Francis J. McMahon, Silvia Buervenich, Dennis Charney, Robert Lipsky, A. John Rush, Alexander F. Wilson, Alexa J. M. Sorant, George J. Papanicolaou, Gonzalo Laje, Maurizio Fava, Madhukar H. Trivedi, Stephen R. Wisniewski, and Husseini Manji
title = Variation in the Gene Encoding the Serotonin 2A Receptor Is Associated with Outcome of Antidepressant Treatment
journal = The American Journal of Human Genetics
year = 2006
month = May
volume = 78
issue = 5
pages = 804–814
pmid = 16642436
pmcid = 1474035
doi = 10.1086/503820 Comments:
* Cite journal
author = A. Semaka
title = A role for genetics in the outcome of antidepressant treatment for major depressive disorder
journal = Clinical Genetics
volume = 70
issue = 2
pages = 110–111
doi = 10.1111/j.1399-0004.2006.0645_2.x
* Cite journal
author = Aaron Levin
title = Genes Have a Lot to Say About Depression Treatment Results
journal = Psychiatr. News
volume = 41
issue = 10
pages = 45
year = 2006
month = May
url = http://pn.psychiatryonline.org/cgi/content/full/41/10/45] The research group reported that a polymorphism (rs1954787) on another gene, the GRIK4, has also shown a treatment-response-association in this kind of treatment. [Cite journal
author = Silvia Paddock, Gonzalo Laje, Dennis Charney, A. John Rush, Alexander F. Wilson, Alexa J.M. Sorant, Robert Lipsky, Stephen R. Wisniewski, Husseini Manji and Francis J. McMahon
title = Association of GRIK4 With Outcome of Antidepressant Treatment in the STAR*D Cohort
journal = Am J Psychiatry
volume = 164
pages = 1181–1188
month = August
year = 2007
doi = 10.1176/appi.ajp.2007.06111790
url = http://ajp.psychiatryonline.org/cgi/content/abstract/164/8/1181]

Rs6311, rs6313 and His452Tyr (rs6314) are other SNPs in the HTR2A gene.There are many more, even in intron 2 alone. [Cite web
url = http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?chooseRs=all&locusId=3356
title = SNP linked to Gene HTR2A
accessdate = 2008-09-08
publisher = NCBI]

References