Salt-and-pepper chromatin

Salt-and-pepper chromatin

In pathology, salt-and-pepper chromatin, also salt-and-pepper nuclei, refers to cell nuclei that demonstrate finely granular chromatin (on light microscopy). [cite journal |author=Chetty R, Asa SL |title=Pancreatic endocrine tumour with cytoplasmic keratin whorls. Is the term "rhabdoid" appropriate? |journal=J. Clin. Pathol. |volume=57 |issue=10 |pages=1106–10 |year=2004 |month=October |pmid=15452172 |pmc=1770450 |doi=10.1136/jcp.2004.018309 |url=]

Salt-and-pepper chromatin is typically seen in endocrine tumours such as medullary thyroid carcinoma, carcinoids [cite journal |author=Van Buren G, Rashid A, Yang AD, "et al" |title=The development and characterization of a human midgut carcinoid cell line |journal=Clin. Cancer Res. |volume=13 |issue=16 |pages=4704–12 |year=2007 |month=August |pmid=17699847 |doi=10.1158/1078-0432.CCR-06-2723 |url=] and pheochromocytoma. [cite journal |author=Shidham VB, Galindo LM |title=Pheochromocytoma. Cytologic findings on intraoperative scrape smears in five cases |journal=Acta Cytol. |volume=43 |issue=2 |pages=207–13 |year=1999 |pmid=10097711 |doi= |url=]


=Additional

References

External links

* [http://www.nature.com/modpathol/journal/v15/n5/fig_tab/3880561f1.html Salt-and-pepper chromatin] - nature.com.
* [http://path.upmc.edu/cpcases/case1/surgpath.html Salt-and-pepper nucleus] - upmc.edu.


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