Apiol

Apiol

Chembox new
Name = Apiol
ImageFile = Apiol acsv.svg
ImageName = Apiol
IUPACName = 1-allyl-2,5-dimethoxy-
3,4-methylenedioxybenzene
Section1 = Chembox Identifiers
CASNo = 523-80-8
SMILES = C=CCC1=C(OC)C2=C
(OCO2)C(OC)=C1

Section2 = Chembox Properties
Formula = C12H14O4
MolarMass = 222.23 g/mol
Density =
MeltingPt = 30 °C
BoilingPt = 294 °C

Apiol is an organic chemical compound, also known as parsley apiol, apiole or parsley camphor. It is found in celery, parsley seeds, and the essential oil of parsley. Heinrich Christoph Link, an apothecary in Leipzig, discovered the substance in 1715 as greenish crystals reduced by steam from oil of parsley. In 1855 Joret and Homolle discovered that apiol was an effective treatment of amenorrea or lack of menstruation.

In medicine it has been used, as essential oil or in purified form, for the treatment of menstrual disorders. It is an irritant and in high doses it is toxic and can cause liver and kidney damage.

Hippocrates wrote about parsley as a herb to cause an abortion. This effect was caused by the apiol.

Apiol was used by women in the Middle Ages to terminate pregnancies. Fact|date=March 2007 Its use was widespread in the USA, often as ergoapiol or apergol, until a highly toxic adulterated product containing apiol and tri-orthocresyl phosphate (also famous as the adulterant added to Jamaican ginger) was introduced on the American market.

The toxic effects of pure crystalline apiol are disputed. It causes a "relatively safe abortion" in pregnant women if taken in small quantities. It also restores the cycle of menstruation. A larger dose does not cause an abortion, it causes nausea and damages the liver and kidneys. Fact|date=March 2007

Now that other methods of abortion are available apiol is almost forgotten in the West, but it is still produced and is used in the Middle East. Fact|date=March 2007

The name apiol is also used for other closely related compounds, found in dill (dillapiole, 1-allyl-2,3-dimethoxy-4,5-methylenedioxybenzene) and in fennel roots.

External links

* [http://www.henriettesherbal.com/eclectic/bpc1911/petroselinum_apio.html The British Pharmaceutical Codex 1911: Apiol]
* [http://www.chemindustry.com/apps/chemicals?m=d&i=169023 Apiol chemical information from chemindustry.com]
* [http://chem.sis.nlm.nih.gov/chemidplus/direct.jsp?name=Apiole NIH ChemIDplus: Apiole)]
* [http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~GFOqCJ:7 Essential oil from fennel plants--studies on the composition]

References

* Edward Shorter: A history of women's bodies New York 1982 "Bulletin géneral de thérapeutique médicale", No. 158, 1909 (A history of apiol and abortions)


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  • apiol — apiol …   Dictionnaire des rimes

  • Apiol — structure de l Apiol Général Nom IUPAC 4,7 diméthoxy 5 (prop 2 én 1 yl) 1,3 benzodioxole …   Wikipédia en Français

  • apiol — APIÓL s.n. (farm.) Ulei extras din seminţele de pătrunjel şi care serveşte la producerea menstruaţiei şi ca febrifug. [pr.: pi ol] – Din fr. apiol. Trimis de cata, 29.02.2004. Sursa: DEX 98  apiól s. n. (sil. pi ol) Trimis de siveco, 10.08.2004 …   Dicționar Român

  • apiol — [ apjɔl ] n. m. • 1856; du lat. apium « persil » ♦ Pharm. Principe actif, extrait des graines de persil, employé comme emménagogue et fébrifuge. ● apiol nom masculin (latin apium, persil) Principe actif des graines de persil, ayant des propriétés …   Encyclopédie Universelle

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  • Apiol — A pi*ol, n. [L. apium parsley + ol.] (Med.) An oily liquid derived from parsley. [1913 Webster] …   The Collaborative International Dictionary of English

  • Apiōl — Apiōl, s. Petersilie …   Meyers Großes Konversations-Lexikon

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