Leukoencephalopathy with neuroaxonal spheroids

Leukoencephalopathy with neuroaxonal spheroids

Leukoencephalopathy with neuroaxonal spheroids is a special kind of leukoencephalopathy. It is cause of severe and subacute dementia. It is inherited, following an autosomal dominant pattern

It usually presents in childhood but it can also have an adult onset. In this case, it can present MRIs that mimic those of progressive multiple sclerosis [cite journal |author=Keegan BM, Giannini C, Parisi JE, Lucchinetti CF, Boeve BF, Josephs KA |title=Sporadic adult-onset leukoencephalopathy with neuroaxonal spheroids mimicking cerebral MS |journal=Neurology |volume=70 |issue=13 Pt 2 |pages=1128–33 |year=2008 |month=March |pmid=18287567 |doi=10.1212/01.wnl.0000304045.99153.8f |url=] .

ee also

*Leukoencephalopathy

References


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  • Leukoencephalopathy — The term Leukoencephalopathy is a broad term for leukodystrophy like diseases (PMID 17414998). It is applied to all brain white matter diseases, whether their molecular cause is known. It can refer specifically to any of these… …   Wikipedia

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