Seminoma

Seminoma

Seminoma is one type of testicular cancer [DorlandsDict|seven/000095781|Seminoma] that is believed to originate from the germinal epithelium of the seminiferous tubules.

Presentation

They produce bulky masses that can be up to ten times the size of a normal testis.

Diagnosis

Gene|POU2AF1 and Gene|PROM1 have been proposed as possible markers.cite journal |author=Gashaw I, Dushaj O, Behr R, "et al" |title=Novel germ cell markers characterize testicular seminoma and fetal testis |journal=Mol. Hum. Reprod. |volume=13 |issue=10 |pages=721–7 |year=2007 |pmid=17785371 |doi=10.1093/molehr/gam059]

Peak incidence occurs in the 4th decade of life. Histology shows large cells, clear cytoplasm, distinct cell membranes, and septated arcitecture.

Treatment

In recent years, these tumors have been shown to have dramatic sensitivity to both radiotherapy and cytotoxic chemotherapy. The management of childhood seminoma is similar to that of adult seminoma. Orchidectomy is required in almost all cases.

Relation to "spermatocytic seminoma"

Spermatocytic seminomas are not considered a subtype of seminoma and unlike other germ cell tumours do not arise from "intratubular germ cell neoplasia". [cite journal |author=Müller J, Skakkebaek NE, Parkinson MC |title=The spermatocytic seminoma: views on pathogenesis |journal=Int. J. Androl. |volume=10 |issue=1 |pages=147–56 |year=1987 |month=February |pmid=3583416 |doi= |url=]


=Additional

References


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Look at other dictionaries:

  • Seminoma — Imagen histopatológica de un seminoma metastásico en un ganglio linfático inguinal. Clas …   Wikipedia Español

  • seminoma — m. oncol. Tumor maligno que se desarrolla en el testículo a partir de las células germinales indiferenciadas. Es un tumor muy sensible a la radioterapia y si se detecta a tiempo tiene muy buen pronóstico. Suele afectar especialmente a sujetos… …   Diccionario médico

  • seminoma — [sem΄i nō′mə] n. pl. seminomas, seminomata a type of malignant tumor that forms in a testicle * * * sem·i·no·ma (sĕm ə nōʹmə) n. pl. sem·i·no·mas or sem·i·no·ma·ta ( mə tə) A malignant tumor of the testis arising from sperm forming tissue.  … …   Universalium

  • seminoma — [sem΄i nō′mə] n. pl. seminomas, seminomata a type of malignant tumor that forms in a testicle …   English World dictionary

  • seminoma ovárico — Véase disgerminoma. Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A. 1999 …   Diccionario médico

  • seminoma — noun A form of testicular cancer …   Wiktionary

  • seminoma — A radiosensitive malignant neoplasm usually arising from germ cells in the testis of young male adults which metastasizes to the paraortic lymph node s; a counterpart of dysgerminoma of the ovary. [L. semen, seed (semen) + G. oma …   Medical dictionary

  • seminoma — ► sustantivo masculino MEDICINA Variedad de tumor maligno que se desarrolla en un testículo. * * * ► masculino PATOLOGÍA Tumor maligno del testículo desarrollado a partir del epitelio seminal …   Enciclopedia Universal

  • seminoma — se|mi|no|ma Mot Pla Nom masculí …   Diccionari Català-Català

  • seminoma — se·mi·nò·ma s.m. TS med. tumore del testicolo originato dalle cellule germinative che dà luogo a metastasi per via linfatica {{line}} {{/line}} DATA: 1937. ETIMO: der. di semin(ifero) con oma …   Dizionario italiano

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