INHBB

Inhibin, beta B (activin AB beta polypeptide), also known as INHBB, is a human gene.cite web | title = Entrez Gene: INHBB inhibin, beta B (activin AB beta polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3625| accessdate = ]

PBB_Summary
section_title =
summary_text = The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.cite web | title = Entrez Gene: INHBB inhibin, beta B (activin AB beta polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3625| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ying SY |title=Inhibins and activins: chemical properties and biological activity. |journal=Proc. Soc. Exp. Biol. Med. |volume=186 |issue= 3 |pages= 253–64 |year= 1988 |pmid= 3122219 |doi=
*cite journal | author=Munz B, Hübner G, Tretter Y, "et al." |title=A novel role of activin in inflammation and repair. |journal=J. Endocrinol. |volume=161 |issue= 2 |pages= 187–93 |year= 1999 |pmid= 10320815 |doi=
*cite journal | author=Welt CK |title=The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction. |journal=Curr. Opin. Obstet. Gynecol. |volume=14 |issue= 3 |pages= 317–23 |year= 2002 |pmid= 12032389 |doi=
*cite journal | author=Shav-Tal Y, Zipori D |title=The role of activin a in regulation of hemopoiesis. |journal=Stem Cells |volume=20 |issue= 6 |pages= 493–500 |year= 2003 |pmid= 12456957 |doi=
*cite journal | author=Lahlou N, Roger M |title=Inhibin B in pubertal development and pubertal disorders. |journal=Semin. Reprod. Med. |volume=22 |issue= 3 |pages= 165–75 |year= 2005 |pmid= 15319819 |doi= 10.1055/s-2004-831892
*cite journal | author=Mathews LS, Vale WW |title=Expression cloning of an activin receptor, a predicted transmembrane serine kinase. |journal=Cell |volume=65 |issue= 6 |pages= 973–82 |year= 1991 |pmid= 1646080 |doi=
*cite journal | author=Schmelzer CH, Burton LE, Tamony CM, "et al." |title=Purification and characterization of recombinant human activin B. |journal=Biochim. Biophys. Acta |volume=1039 |issue= 2 |pages= 135–41 |year= 1990 |pmid= 2364091 |doi=
*cite journal | author=Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH |title=Activin B: precursor sequences, genomic structure and in vitro activities. |journal=Mol. Endocrinol. |volume=3 |issue= 9 |pages= 1352–8 |year= 1990 |pmid= 2575216 |doi=
*cite journal | author=Feng ZM, Bardin CW, Chen CL |title=Characterization and regulation of testicular inhibin beta-subunit mRNA. |journal=Mol. Endocrinol. |volume=3 |issue= 6 |pages= 939–48 |year= 1989 |pmid= 2739657 |doi=
*cite journal | author=Barton DE, Yang-Feng TL, Mason AJ, "et al." |title=Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice. |journal=Genomics |volume=5 |issue= 1 |pages= 91–9 |year= 1989 |pmid= 2767687 |doi=
*cite journal | author=Burger HG, Igarashi M |title=Inhibin: definition and nomenclature, including related substances. |journal=Endocrinology |volume=122 |issue= 4 |pages= 1701–2 |year= 1988 |pmid= 3345731 |doi=
*cite journal | author=Mason AJ, Niall HD, Seeburg PH |title=Structure of two human ovarian inhibins. |journal=Biochem. Biophys. Res. Commun. |volume=135 |issue= 3 |pages= 957–64 |year= 1986 |pmid= 3754442 |doi=
*cite journal | author=Martens JW, de Winter JP, Timmerman MA, "et al." |title=Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells. |journal=Endocrinology |volume=138 |issue= 7 |pages= 2928–36 |year= 1997 |pmid= 9202237 |doi=
*cite journal | author=Mellor SL, Cranfield M, Ries R, "et al." |title=Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit. |journal=J. Clin. Endocrinol. Metab. |volume=85 |issue= 12 |pages= 4851–8 |year= 2001 |pmid= 11134153 |doi=
*cite journal | author=Chapman SC, Woodruff TK |title=Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP). |journal=Mol. Endocrinol. |volume=15 |issue= 4 |pages= 668–79 |year= 2001 |pmid= 11266516 |doi=
*cite journal | author=Salmenkivi K, Arola J, Voutilainen R, "et al." |title=Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 5 |pages= 2231–5 |year= 2001 |pmid= 11344232 |doi=
*cite journal | author=Bahathiq AO, Stewart RL, Wells M, "et al." |title=Production of activins by the human endosalpinx. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5283–9 |year= 2002 |pmid= 12414903 |doi=

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