- LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, also known as LFNG and Lunatic Fringe, [cite journal | author=Egan S, Herbrick JA, Tsui LC, "et al." |title=Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12. |journal=Genomics |volume=54 |issue= 3 |pages= 576–7 |year= 1999 |pmid= 9878264 |doi= 10.1006/geno.1998.5559 ] is a human
gene .cite web | title = Entrez Gene: LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3955| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the glycosyltransferase superfamily. The encoded protein is a single-pass type II Golgi membrane protein that functions as a fucose-specific glycosyltransferase, adding an N-acetylglucosamine to the fucose residue of a group of signaling receptors involved in regulating cell fate decisions during development. Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Alternatively spliced transcript variants that encode different isoforms have been described, however, not all variants have been fully characterized.cite web | title = Entrez Gene: LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3955| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Johnston SH, Rauskolb C, Wilson R, "et al." |title=A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. |journal=Development |volume=124 |issue= 11 |pages= 2245–54 |year= 1997 |pmid= 9187150 |doi=
*cite journal | author=Moran JL, Johnston SH, Rauskolb C, "et al." |title=Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes. |journal=Mamm. Genome |volume=10 |issue= 6 |pages= 535–41 |year= 1999 |pmid= 10341080 |doi=
*cite journal | author=Moloney DJ, Panin VM, Johnston SH, "et al." |title=Fringe is a glycosyltransferase that modifies Notch. |journal=Nature |volume=406 |issue= 6794 |pages= 369–75 |year= 2000 |pmid= 10935626 |doi= 10.1038/35019000
*cite journal | author=Shimizu K, Chiba S, Saito T, "et al." |title=Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25753–8 |year= 2001 |pmid= 11346656 |doi= 10.1074/jbc.M103473200
*cite journal | author=Cole SE, Levorse JM, Tilghman SM, Vogt TF |title=Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis. |journal=Dev. Cell |volume=3 |issue= 1 |pages= 75–84 |year= 2002 |pmid= 12110169 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shao L, Moloney DJ, Haltiwanger R |title=Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 7775–82 |year= 2003 |pmid= 12486116 |doi= 10.1074/jbc.M212221200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Sparrow DB, Chapman G, Wouters MA, "et al." |title=Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. |journal=Am. J. Hum. Genet. |volume=78 |issue= 1 |pages= 28–37 |year= 2006 |pmid= 16385447 |doi= 10.1086/498879PBB_Controls
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