AFF3

AF4/FMR2 family, member 3, also known as AFF3, is a human gene.cite web | title = Entrez Gene: AFF3 AF4/FMR2 family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3899| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.cite web | title = Entrez Gene: AFF3 AF4/FMR2 family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3899| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ma C, Staudt LM |title=LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. |journal=Blood |volume=87 |issue= 2 |pages= 734–45 |year= 1996 |pmid= 8555498 |doi=
*cite journal | author=Liao X, Ma C, Trask B, "et al." |title=LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12. |journal=Mamm. Genome |volume=7 |issue= 6 |pages= 467–8 |year= 1997 |pmid= 8662235 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=von Bergh AR, Beverloo HB, Rombout P, "et al." |title=LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia. |journal=Genes Chromosomes Cancer |volume=35 |issue= 1 |pages= 92–6 |year= 2002 |pmid= 12203795 |doi= 10.1002/gcc.10091
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hiwatari M, Taki T, Taketani T, "et al." |title=Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23). |journal=Oncogene |volume=22 |issue= 18 |pages= 2851–5 |year= 2003 |pmid= 12743608 |doi= 10.1038/sj.onc.1206389
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=To MD, Faseruk SA, Gokgoz N, "et al." |title=LAF-4 is aberrantly expressed in human breast cancer. |journal=Int. J. Cancer |volume=115 |issue= 4 |pages= 568–74 |year= 2005 |pmid= 15704140 |doi= 10.1002/ijc.20881
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466

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