ZFPM2

Zinc finger protein, multitype 2, also known as ZFPM2, is a human gene.cite web | title = Entrez Gene: ZFPM2 zinc finger protein, multitype 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23414| accessdate = ]

PBB_Summary
section_title =
summary_text = The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence.cite web | title = Entrez Gene: ZFPM2 zinc finger protein, multitype 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23414| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Svensson EC, Tufts RL, Polk CE, Leiden JM |title=Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 3 |pages= 956–61 |year= 1999 |pmid= 9927675 |doi=
*cite journal | author=Fox AH, Liew C, Holmes M, "et al." |title=Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers. |journal=EMBO J. |volume=18 |issue= 10 |pages= 2812–22 |year= 1999 |pmid= 10329627 |doi= 10.1093/emboj/18.10.2812
*cite journal | author=Holmes M, Turner J, Fox A, "et al." |title=hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23491–8 |year= 1999 |pmid= 10438528 |doi=
*cite journal | author=Crispino JD, Lodish MB, Thurberg BL, "et al." |title=Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. |journal=Genes Dev. |volume=15 |issue= 7 |pages= 839–44 |year= 2001 |pmid= 11297508 |doi= 10.1101/gad.875201
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Anttonen M, Ketola I, Parviainen H, "et al." |title=FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression. |journal=Biol. Reprod. |volume=68 |issue= 4 |pages= 1333–40 |year= 2004 |pmid= 12606418 |doi= 10.1095/biolreprod.102.008599
*cite journal | author=Pizzuti A, Sarkozy A, Newton AL, "et al." |title=Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot. |journal=Hum. Mutat. |volume=22 |issue= 5 |pages= 372–7 |year= 2004 |pmid= 14517948 |doi= 10.1002/humu.10261
*cite journal | author=Hirai M, Ono K, Morimoto T, "et al." |title=FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes. |journal=J. Biol. Chem. |volume=279 |issue= 36 |pages= 37640–50 |year= 2004 |pmid= 15220332 |doi= 10.1074/jbc.M401737200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chan EM, Comer EM, Brown FC, "et al." |title=AML1-FOG2 fusion protein in myelodysplasia. |journal=Blood |volume=105 |issue= 11 |pages= 4523–6 |year= 2005 |pmid= 15705784 |doi= 10.1182/blood-2004-07-2762
*cite journal | author=Ackerman KG, Herron BJ, Vargas SO, "et al." |title=Fog2 is required for normal diaphragm and lung development in mice and humans. |journal=PLoS Genet. |volume=1 |issue= 1 |pages= 58–65 |year= 2005 |pmid= 16103912 |doi= 10.1371/journal.pgen.0010010
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Finelli P, Pincelli AI, Russo S, "et al." |title=Disruption of friend of GATA 2 gene (FOG-2) by a de novo t(8;10) chromosomal translocation is associated with heart defects and gonadal dysgenesis. |journal=Clin. Genet. |volume=71 |issue= 3 |pages= 195–204 |year= 2007 |pmid= 17309641 |doi= 10.1111/j.1399-0004.2007.00752.x
*cite journal | author=Bleyl SB, Moshrefi A, Shaw GM, "et al." |title=Candidate genes for congenital diaphragmatic hernia from animal models: sequencing of FOG2 and PDGFRalpha reveals rare variants in diaphragmatic hernia patients. |journal=Eur. J. Hum. Genet. |volume=15 |issue= 9 |pages= 950–8 |year= 2007 |pmid= 17568391 |doi= 10.1038/sj.ejhg.5201872

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