HRK (gene)

HRK (gene)
Harakiri, BCL2 interacting protein (contains only BH3 domain)
Identifiers
Symbols HRK; DP5; HARAKIRI
External IDs OMIM603447 MGI1201608 HomoloGene37853 GeneCards: HRK Gene
RNA expression pattern
PBB GE HRK 206865 at tn.png
PBB GE HRK 206864 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8739 12123
Ensembl ENSG00000135116 ENSMUSG00000046607
UniProt O00198 n/a
RefSeq (mRNA) NM_003806 NM_007545.2
RefSeq (protein) NP_003797 NP_031571.1
Location (UCSC) Chr 12:
117.3 – 117.32 Mb
Chr 5:
118.62 – 118.64 Mb
PubMed search [1] [2]

Activator of apoptosis harakiri is a protein that in humans is encoded by the HRK gene.[1][2]

Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.[2]

Interactions

HRK (gene) has been shown to interact with BCL2-like 1[1][3][4] and Bcl-2.[1][5]

References

  1. ^ a b c Inohara N, Ding L, Chen S, Nunez G (May 1997). "harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". EMBO J 16 (7): 1686–94. doi:10.1093/emboj/16.7.1686. PMC 1169772. PMID 9130713. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169772. 
  2. ^ a b "Entrez Gene: HRK harakiri, BCL2 interacting protein (contains only BH3 domain)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8739. 
  3. ^ Whitfield, Jonathan; Harada Kokichi, Bardelle Catherine, Staddon James M (Nov. 2003). "High-throughput methods to detect dimerization of Bcl-2 family proteins". Anal. Biochem. (United States) 322 (2): 170–8. doi:10.1016/j.ab.2003.07.014. ISSN 0003-2697. PMID 14596824. 
  4. ^ Imaizumi, K; Morihara T, Mori Y, Katayama T, Tsuda M, Furuyama T, Wanaka A, Takeda M, Tohyama M (Mar. 1999). "The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein". J. Biol. Chem. (UNITED STATES) 274 (12): 7975–81. doi:10.1074/jbc.274.12.7975. ISSN 0021-9258. PMID 10075695. 
  5. ^ Chen, Lin; Willis Simon N, Wei Andrew, Smith Brian J, Fletcher Jamie I, Hinds Mark G, Colman Peter M, Day Catherine L, Adams Jerry M, Huang David C S (Feb. 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell (United States) 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. ISSN 1097-2765. PMID 15694340. 

Further reading




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