DDX3Y

DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked

PDB rendering based on 2i4i.
Identifiers
Symbols DDX3Y; DBY
External IDs OMIM400010 MGI91842 HomoloGene55839 GeneCards: DDX3Y Gene
EC number 3.6.4.13
RNA expression pattern
PBB GE DDX3Y 205000 at tn.png
PBB GE DDX3Y 205001 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8653 110957
Ensembl ENSG00000067048 ENSMUSG00000039224
UniProt O15523 P16381
RefSeq (mRNA) NM_001122665.1 NM_033077.2
RefSeq (protein) NP_001116137.1 NP_149068.1
Location (UCSC) Chr Y:
15.02 – 15.03 Mb
Chr 1:
188.79 – 188.79 Mb
PubMed search [1] [2]

ATP-dependent RNA helicase DDX3Y is an enzyme that in humans is encoded by the DDX3Y gene.[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome (DDX3X). The gene mutation causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Alternative splicing of this gene generates 2 transcripts, which differ only in the length of the 3' UTR.[2]

References

  1. ^ Lahn BT, Page DC (Nov 1997). "Functional coherence of the human Y chromosome". Science 278 (5338): 675–80. doi:10.1126/science.278.5338.675. PMID 9381176. 
  2. ^ a b "Entrez Gene: DDX3Y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8653. 

Further reading