SH2B2

SH2B adaptor protein 2, also known as SH2B2, is a human gene.cite web | title = Entrez Gene: SH2B2 SH2B adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10603| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.cite web | title = Entrez Gene: SH2B2 SH2B adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10603| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yokouchi M, Suzuki R, Masuhara M, "et al." |title=Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation. |journal=Oncogene |volume=15 |issue= 1 |pages= 7–15 |year= 1997 |pmid= 9233773 |doi= 10.1038/sj.onc.1201163
*cite journal | author=Glöckner G, Scherer S, Schattevoy R, "et al." |title=Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. |journal=Genome Res. |volume=8 |issue= 10 |pages= 1060–73 |year= 1998 |pmid= 9799793 |doi=
*cite journal | author=Qian X, Riccio A, Zhang Y, Ginty DD |title=Identification and characterization of novel substrates of Trk receptors in developing neurons. |journal=Neuron |volume=21 |issue= 5 |pages= 1017–29 |year= 1999 |pmid= 9856458 |doi=
*cite journal | author=Yokouchi M, Wakioka T, Sakamoto H, "et al." |title=APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. |journal=Oncogene |volume=18 |issue= 3 |pages= 759–67 |year= 1999 |pmid= 9989826 |doi= 10.1038/sj.onc.1202326
*cite journal | author=Moodie SA, Alleman-Sposeto J, Gustafson TA |title=Identification of the APS protein as a novel insulin receptor substrate. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11186–93 |year= 1999 |pmid= 10196204 |doi=
*cite journal | author=Wakioka T, Sasaki A, Mitsui K, "et al." |title=APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl. |journal=Leukemia |volume=13 |issue= 5 |pages= 760–7 |year= 1999 |pmid= 10374881 |doi=
*cite journal | author=Iseki M, Takaki S, Takatsu K |title=Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 1 |pages= 45–54 |year= 2000 |pmid= 10872802 |doi= 10.1006/bbrc.2000.2736
*cite journal | author=O'Brien KB, O'Shea JJ, Carter-Su C |title=SH2-B family members differentially regulate JAK family tyrosine kinases. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8673–81 |year= 2002 |pmid= 11751854 |doi= 10.1074/jbc.M109165200
*cite journal | author=Liu J, Kimura A, Baumann CA, Saltiel AR |title=APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3599–609 |year= 2002 |pmid= 11997497 |doi=
*cite journal | author=Yabana N, Shibuya M |title=Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. |journal=Oncogene |volume=21 |issue= 50 |pages= 7720–9 |year= 2002 |pmid= 12400014 |doi= 10.1038/sj.onc.1205927
*cite journal | author=Ahn MY, Katsanakis KD, Bheda F, Pillay TS |title=Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling. |journal=J. Biol. Chem. |volume=279 |issue= 20 |pages= 21526–32 |year= 2004 |pmid= 15031295 |doi= 10.1074/jbc.M307740200
*cite journal | author=Wilcox A, Katsanakis KD, Bheda F, Pillay TS |title=Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex. |journal=J. Biol. Chem. |volume=279 |issue= 37 |pages= 38881–8 |year= 2004 |pmid= 15231829 |doi= 10.1074/jbc.M406101200
*cite journal | author=Hu J, Hubbard SR |title=Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins. |journal=J. Biol. Chem. |volume=280 |issue= 19 |pages= 18943–9 |year= 2005 |pmid= 15737992 |doi= 10.1074/jbc.M414157200
*cite journal | author=Iseki M, Kubo-Akashi C, Kwon SM, "et al." |title=APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 3 |pages= 1005–13 |year= 2005 |pmid= 15809095 |doi= 10.1016/j.bbrc.2005.03.073
*cite journal | author=Katsanakis KD, Pillay TS |title=Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. |journal=J. Biol. Chem. |volume=280 |issue= 45 |pages= 37827–32 |year= 2006 |pmid= 16141217 |doi= 10.1074/jbc.M505959200
*cite journal | author=Li M, Li Z, Morris DL, Rui L |title=Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling. |journal=Endocrinology |volume=148 |issue= 4 |pages= 1615–21 |year= 2007 |pmid= 17204555 |doi= 10.1210/en.2006-1010

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